Registration Dossier
Registration Dossier
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EC number: 201-155-9 | CAS number: 78-90-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
- Principles of method if other than guideline:
- other: BASF Test
- GLP compliance:
- no
Test material
- Reference substance name:
- Propylenediamine
- EC Number:
- 201-155-9
- EC Name:
- Propylenediamine
- Cas Number:
- 78-90-0
- Molecular formula:
- C3H10N2
- IUPAC Name:
- propane-1,2-diamine
- Details on test material:
- - Name of test material (as cited in study report): 1,2-Propylendiamin
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 25, 50, 100, 125, 160, 200, 1600 µl/kg bw ( 21.5, 43, 80, 108, 138, 172, 1376 mg/kg bw; conversion into mg/kg is based on the density d= 0.86 g/cm3 - according to BASF internal data)
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 140 mg/kg bw
- Remarks on result:
- other: conversion into mg/kg is based on the density d= 0.8 g/cm3 - according to BASF internal data
- Mortality:
- 1376 mg/kg bw: 10/10 within 24 h
172 mg/kg bw: 7/10 within 24 h and all 10 animals within 7 days.
138 mg/kg bw: 1/20 within 48 h and 10/20 within 7 days.
108 mg/kg bw: 1/20 within 48 h and 2/20 within 7 days.
80 mg/kg bw. 1/10 within 48 h.
21.5, 43 mg/kg bw: no mortalities. - Clinical signs:
- Staggering, prone and side positions, spring spasms, and belated death.
- Body weight:
- no data
- Gross pathology:
- Local irritations
Applicant's summary and conclusion
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