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EC number: 203-898-4 | CAS number: 111-71-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2d Test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Heptanal
- EC Number:
- 203-898-4
- EC Name:
- Heptanal
- Cas Number:
- 111-71-7
- Molecular formula:
- C7H14O
- IUPAC Name:
- heptanal
- Details on test material:
- - Name of test material (as cited in study report): heptanal
- Substance type: aldehyde
- Physical state: no data
- Analytical purity: 98-99 %
- Purity test date: no data
- Lot/batch No.: 810319
- Expiration date of the lot/batch: no data
- Stability under test conditions: the test substance was judged to be stable for the duration of the study.
- Storage condition of test material: in the dark at ambient temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Shell Toxicology Laboratory (Tunstall)
- Age at study initiation: 10 weeks
- Weight at study initiation: males 251-328 g; females 180 - 220 g
- Fasting period before study: no data
- Housing: individually
- Diet : ad libitum (PRD, Labsure Animal Foods Ltd.)
- Water : ad libitum (filtered but untreated water from the public supply)
- Acclimation period: Rats were bred in the Shell Toxicology Laboratory.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approximately 20
- Humidity (%): 58-70
- Air changes (per hr): no data
- Photoperiod : 12 hrs dark / 12 hrs light
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: two tubular glass chambers
- Exposure chamber volume: 7 l
- Method of holding animals in test chamber: no data
- Source and rate of air: The test atmosphere was supplied at a minimal flow rate of 10 litres per minute
- Method of conditioning air: no data
- System of generating particulates/aerosols: the test atmosphere was generated by passing 3 to 4 l min -1 of nitrogen through a wick type saturator maintained at 78°C in a thermostated water bath. The vapou/air mixture was diluted with air at a flow rate of approximately 16 l min -1 before delivery to two identical, glass inhalation chambers each of volume 7 litres.
- Treatment of exhaust air: no data
- Temperature, humidity, pressure in air chamber: no data
TEST ATMOSPHERE
- Brief description of analytical method used: The concentration of the heptanal in the test atmosphere was measured continuously throughout the exposure by means of a Miran infra-red gas analyser. The latter was calibrated by injecting known volumes of heptanal into a closed loop circulating system also of known volume including the analyser gas cell.
- Samples taken from breathing zone: no - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 18.4 mg/l
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were observed for toxic signs at frequent intervals throughout the exposure. Afterwards animals were observed daily for toxic signs over the following 14 days. Body weights were recorded initially and after 7 and 14 days.
- Necropsy of survivors performed: no
- Other examinations performed: no data - Statistics:
- Studen's t test was used to compare body weight between treated and control animals.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 18.4 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: Exposure concentration was near saturated
- Mortality:
- The one male rat that died within 5 minutes of the cessation of exposure was examined histopathologically. Since no other rats died or showed any macroscopic abnormalities at necropsy, it was concluded that the single death was not directly related to exposure.
- Clinical signs:
- other: Signs of intoxication that persited throughout the exposure period included rapid respiration, eye and nasal irritation, salivation and a general state of agitation. The female rats recovered within 48 hours, however some of the signs persisted in the mal
- Body weight:
- Body weights of the exposed group of animals increased normally during the observation period and mean body weights of the test and control groups were not significantly different (Studen's t test)
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU and CLP classification
- Conclusions:
- Under the conditions of this test, no mortality was directly related to the exposure.
- Executive summary:
In an acute inhalation toxicity study (Shell, 1982), a group of 5 male and 5 female rats was exposed for 4 hours to a mean concentration of 18.4 mg/l of heptanal a near saturated atmosphere. Signs of intoxication that persited throughout the exposure period included rapid respiration, eye and nasal irritation, salivation and a general state of agitation. The female rats recovered within 48 hours, however some of the signs persisted in the male rats for the whole of the 14 day post exposure period. Body weights of the exposed group of animals increased normally during the observation period and mean body weights of the test and control groups were not significantly different (Studen's t test). The one male rat that died within 5 minutes of the cessation of exposure was examined histopathologically. Since no other rats died or showed any macroscopic abnormalities at necropsy, it was concluded that the single death was not directly related to exposure. Then, the acute 4 h inhalation LC50 (and LC0) of heptanal in Wistar rats is greater than 18.4 mg/l a concentration which is near saturated.
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