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EC number: 235-166-5 | CAS number: 12108-13-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not mentioned.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- information on animal husbandry and environmental conditions was not provided.
- GLP compliance:
- no
- Remarks:
- Study conducted prior to GLP guidelines
Test material
- Reference substance name:
- Tricarbonyl(methylcyclopentadienyl)manganese
- EC Number:
- 235-166-5
- EC Name:
- Tricarbonyl(methylcyclopentadienyl)manganese
- Cas Number:
- 12108-13-3
- Molecular formula:
- C9H7MnO3
- IUPAC Name:
- tricarbonyl(methyl-η5-cyclopentadienyl)manganese
- Details on test material:
- - Name of test material: MMT Tecnhical
- Physical state: Amber liquid
- Analytical purity: Not mentioned
- Purity test date: No mentioned
- Lot/batch No.: 548-76
Please refer to section 13 "Purity statement".
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Not mentioned
- Age at study initiation: Not mentioned
- Weight at study initiation: 1.9-2.3 kg
- Housing: Individually housed
- Diet : Not mentioned
- Water : Not mentioned
- Acclimation period: Not mentioned
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 ml
- Concentration : 100%
- Duration of treatment / exposure:
- The test substance was administrated to the eye of the rabbit, and not further removed.
- Observation period (in vivo):
- Animals were observed for 7 days post-exposure as symptoms persisted at maximum of 4 days post-dosage.
- Number of animals or in vitro replicates:
- Six rabbits.
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: No
- Time after start of exposure: N.A.
SCORING SYSTEM: Check below "Any other information on materials and methods incl. tables".
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- See Table 1 and Table 2
Any other information on results incl. tables
Table 1 - Individual score for eye irritation
Animals No. |
Time after administration - Days |
Positive score |
||||
1 |
2 |
3 |
4 |
7 |
||
791 |
||||||
1. Cornea |
||||||
A. Opacity |
0 |
0 |
0 |
0 |
0 |
No |
B. Stippling |
0 |
0 |
0 |
0 |
0 |
No |
D. Ulceration |
0 |
0 |
0 |
0 |
0 |
No |
Score |
0 |
0 |
0 |
0 |
0 |
No |
2. Iris |
0 |
0 |
0 |
0 |
0 |
No |
Score |
0 |
0 |
0 |
0 |
0 |
|
3. Conjunctivae |
||||||
A. Redness |
1 |
0 |
0 |
0 |
0 |
No |
B. Chemosis |
1 |
0 |
0 |
0 |
0 |
No |
C. Discharge |
0 |
0 |
0 |
0 |
0 |
|
D. Necrosis Or Ulceration |
0 |
0 |
0 |
0 |
0 |
No |
Score |
4 |
0 |
0 |
0 |
0 |
|
Total score |
4 |
0 |
0 |
0 |
0 |
|
792 |
||||||
1. Cornea |
||||||
A. Opacity |
0 |
0 |
0 |
0 |
0 |
No |
B. Stippling |
0 |
0 |
0 |
0 |
0 |
|
D. Ulceration |
0 |
0 |
0 |
0 |
0 |
No |
Score |
0 |
0 |
0 |
0 |
0 |
|
2. Iris |
0 |
0 |
0 |
0 |
0 |
No |
Score |
0 |
0 |
0 |
0 |
0 |
|
3. Conjunctivae |
||||||
A. Redness |
1 |
1 |
0 |
0 |
0 |
No |
B. Chemosis |
0 |
0 |
0 |
0 |
0 |
No |
C. Discharge |
0 |
0 |
0 |
0 |
0 |
|
D. Necrosis Or Ulceration |
0 |
0 |
0 |
0 |
0 |
No |
Score |
2 |
2 |
0 |
0 |
0 |
|
Total score |
2 |
2 |
0 |
0 |
0 |
|
793 |
||||||
1. Cornea |
||||||
A. Opacity |
0 |
0 |
0 |
0 |
0 |
No |
B. Stippling |
0 |
0 |
0 |
0 |
0 |
|
D. Ulceration |
0 |
0 |
0 |
0 |
0 |
No |
Score |
0 |
0 |
0 |
0 |
0 |
|
2. Iris |
0 |
0 |
0 |
0 |
0 |
No |
Score |
0 |
0 |
0 |
0 |
0 |
|
3. Conjunctivae |
||||||
A. Redness |
1 |
0 |
0 |
0 |
0 |
No |
B. Chemosis |
1 |
0 |
0 |
0 |
0 |
No |
C. Discharge |
0 |
0 |
0 |
0 |
0 |
|
D. Necrosis Or Ulceration |
0 |
0 |
0 |
0 |
0 |
No |
Score |
4 |
0 |
0 |
0 |
0 |
|
Total score |
4 |
0 |
0 |
0 |
0 |
|
794 |
||||||
1. Cornea |
||||||
A. Opacity |
0 |
0 |
0 |
0 |
0 |
No |
B. Stippling |
0 |
0 |
0 |
0 |
0 |
|
D. Ulceration |
0 |
0 |
0 |
0 |
0 |
No |
Score |
0 |
0 |
0 |
0 |
0 |
|
2. Iris |
0 |
0 |
0 |
0 |
0 |
No |
Score |
0 |
0 |
0 |
0 |
0 |
|
3. Conjunctivae |
||||||
A. Redness |
0 |
0 |
0 |
0 |
0 |
No |
B. Chemosis |
0 |
0 |
0 |
0 |
0 |
No |
C. Discharge |
0 |
0 |
0 |
0 |
0 |
|
D. Necrosis Or Ulceration |
0 |
0 |
0 |
0 |
0 |
No |
Score |
0 |
0 |
0 |
0 |
0 |
|
Total score |
0 |
0 |
0 |
0 |
0 |
|
796 |
||||||
1. Cornea |
||||||
A. Opacity |
0 |
|
|
|
|
|
B. Stippling |
0 |
|
|
|
|
|
D. Ulceration |
0 |
|
|
|
|
|
Score |
0 |
|
|
|
|
|
2. Iris |
0 |
|
|
|
|
|
Score |
0 |
|
|
|
|
|
3. Conjunctivae |
||||||
A. Redness |
1 |
1 |
1 |
0 |
0 |
No |
B. Chemosis |
0 |
0 |
0 |
0 |
0 |
No |
C. Discharge |
0 |
0 |
0 |
0 |
0 |
|
D. Necrosis Or Ulceration |
0 |
0 |
0 |
0 |
0 |
No |
Score |
2 |
2 |
2 |
0 |
0 |
|
|
2 |
2 |
2 |
0 |
0 |
|
798 |
||||||
1. Cornea |
||||||
A. Opacity |
0 |
0 |
0 |
0 |
0 |
No |
B. Stippling |
0 |
0 |
0 |
0 |
0 |
|
D. Ulceration |
0 |
0 |
0 |
0 |
0 |
No |
Score |
0 |
0 |
0 |
0 |
0 |
|
2. Iris |
0 |
0 |
0 |
0 |
0 |
No |
Score |
0 |
0 |
0 |
0 |
0 |
|
3. Conjunctivae0 |
||||||
A. Redness |
1 |
1 |
0 |
0 |
0 |
No |
B. Chemosis |
0 |
0 |
0 |
0 |
0 |
No |
C. Discharge |
0 |
1 |
0 |
0 |
0 |
|
D. Necrosis Or Ulceration |
0 |
0 |
0 |
0 |
0 |
No |
Score |
2 |
4 |
0 |
0 |
0 |
|
Total score |
2 |
4 |
0 |
0 |
|
|
Table 2 - Summary of response and Maximum Draize Scores
Positive (+) or Negative (-) Scores |
|||||||
|
Conjunctivae |
|
|||||
Animal Number |
Cornea |
Iris |
Redness |
Chemosis |
Necrosis or Ulceration |
Clear at Day |
Maximum Draize score |
791 |
- |
- |
- |
- |
- |
2 |
2 |
792 |
- |
- |
- |
- |
- |
3 |
2 |
793 |
- |
- |
- |
- |
- |
2 |
4 |
794 |
- |
- |
- |
- |
- |
1 |
0 |
796 |
- |
- |
- |
- |
- |
4 |
2 |
798 |
- |
- |
- |
- |
- |
3 |
4 |
Total |
0 |
0 |
0 |
0 |
0 |
|
14 |
|
Mean: 2 |
||||||
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- mmt did not produce a response indicative ocular irritation upon direct contact with the eye.
- Executive summary:
In this eye irritation study, 0.1 ml of mmt- technical was instilled into the conjunctival sac of six albino New Zealand rabbits. No effects were observed 7 dayts post exposure , so the study was terminated. Irritation was scored by the method of Draize. The main observed effect was a mild conjunctivae, some vessels injected (score 1), in 5 of the 6 animals exposed, and a mild chemosis in one animal (score 1). The few irritations observed lasted at maximum 4 days in the animals. mmt would not be classified as an eye irritant per EC/1272/2008.
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
