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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
12.03.-09.04.2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
no
Type of method:
effusion method: vapour pressure balance
Temp.:
20 °C
Vapour pressure:
0 Pa
Key result
Temp.:
25 °C
Vapour pressure:
0.001 Pa
Temp.:
50 °C
Vapour pressure:
0.003 Pa

The vapour pressure was measured in the temperature range of 40 °C to 105 °C. After the measurement the measuring cell was empty. The last measurement temperature of 105 °C could not be evaluated as is assumed that the measuring cell was empty after the measurement of 100 °C. The measured vapour pressures at the corresponding temperatures of 40 °C to 100 °C are listed in Table 1.

Table 1: Measured vapour pressures and corresponding temperatures

Temperature/ °C

Vapour pressure/ hPa

40

1.9E-5

50

3.1E-5

60

9.4E-5

70

3.3E-4

75

6.1E-4

80

1.1E-3

85

1.6E-3

90

2.7E-3

95

3.8E-3

100

8.0E-3

The measured vapour pressure at 40 °C was most likely caused by volatile impurities and was therefore not taken into account for the evaluation of the vapour pressure. The values for 20, 25 and 50 °C are calculated, using the Antoine equation.

T/ °C

p/ hPa

p/ Pa

20

4.6E-7

4.6E-5

25

9.7E-7

9.7E-5

50

3.0E-5

3.0E-3

Conclusions:
The vapour pressure of the test item was calculated to be 4.6E-5 Pa at 20 °C, 9.7E-5 Pa at 25 °C and 3.0E-5 Pa at 50 °C, respectively.
Executive summary:

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method (vapo ur pressure balance). The vapour pressure was measured in the temperature range of 40 °C to 105 °C. After the measurement the measuring cell was empty. The last measurement temperature of 105 °C could not be evaluated as is assumed that the measuring cell was empty after the measurement of 100 °C. The vapour pressure of the test item was calculated to be 4.6E-5 Pa at 20 °C, 9.7E-5 Pa at 25 °C and 3.0E-5 Pa at 50 °C, respectively.

Description of key information

The vapour pressure of the test item was calculated to be 4.6E-5 Pa at 20 °C, 9.7E-5 Pa at 25 °C and 3.0E-5 Pa at 50 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method (vapour pressure balance). The vapour pressure was measured in the temperature range of 40 °C to 105 °C.After the measurement the measuring cell was empty. The last measurement temperature of 105 °C could not be evaluated as is assumed that the measuring cell was empty after the measurement of 100 °C.The vapour pressure of the test item was calculated to be 4.6E-5 Pa at 20 °C, 9.7E-5 Pa at 25 °C and 3.0E-5 Pa at 50 °C, respectively.

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