Registration Dossier
Registration Dossier
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EC number: 265-200-4 | CAS number: 64742-96-7 A complex combination of hydrocarbons obtained from the distillation of crude oil or natural gasoline. It consists predominantly of saturated hydrocarbons having carbon numbers predominantly in the range of C11 through C16 and boiling in the range of approximately 190°C to 290°C (374°F to 554°F).
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
- Type of study / information:
- Type: other: nephrotoxicity
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- most likley 8008-20-6
- IUPAC Name:
- most likley 8008-20-6
- Test material form:
- other: low viscosity liquid hydrocarbon
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Exposure to keosine can cause light hydrocarbon nephropathy in male rats. This male rat specific finding is reagerded as not relevant to human health
- Executive summary:
The characteristic nephropathy shown by male rats when exposed to naphtha fractions used in blending gasoline has also been observed with kerosine-type jet fuels. Bruner and Pitts recorded such findings in a 90-day inhalation study with Fischer 344 rats using petroleum-derived jet fuels JP-4 and JP-5 at atmospheric concentrations of 0.15 to 1.0 mg/l. It is accepted that this effect is not relevant for humans.
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