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Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is highly insoluble in water, hence indicating that aquatic toxicity is unlikely to occur
Justification for type of information:
According to QSAR estimation methods for the three known components of C.I. Solvent Blue 98 (3 Amine), the water solubility ranged anywhere from 4.0E-008 to 1.2 mg/L. Using the flask method, the water solubility of C.I. Solvent Blue 98 (3 Amine) was empirically determined to be 0.319 mg/L at 20°C. Using the HPLC method, the n-octanol/water partition coefficient was determined to range from 1.0E006 to greater than 3.2E006 (i.e. log Kow of 6.01 to >6.5). This was also similar to the Log Kow estimates for the known components of C.I. Solvent 98 (3 amine) according to KOWWIN (v. 1.43) which predicted log Kow values ranging from 4.2 to 11.0.
Using the ECOSAR program (developed by the US Environmental Protection Agency’s Office of Chemical Safety and Pollution Prevention, v 1.11), the predicted effect levels for acute toxicity to fish exceeded the estimated water solubility of the chemical structures evaluated. In some cases toxic effects were predicted at concentrations 10-fold greater than the predicted water solubility limit. Thus, no acute effects at water saturation were predicted for the test material, and the study was deemed scientifically not necessary.

No acute effects at water saturation were predicted for the test material, therefore acute testing with fish is waived since the study is scientifically not necessary.

Description of key information

According to QSAR estimation methods for the three known components of C.I. Solvent Blue 98 (3 Amine), the water solubility ranged anywhere from 4.0E-008 to 1.2 mg/L. Using the flask method, the water solubility of C.I. Solvent Blue 98 (3 Amine) was empirically determined to be 0.319 mg/L at 20°C. Using the HPLC method, then-octanol/water partition coefficient was determined to range from 1.0E006 to greater than 3.2E006 (i.e. log Kow of 6.01 to >6.5). This was also similar to the Log Kow estimates for the known components of C.I. Solvent 98 (3 amine) according to KOWWIN (v. 1.43) which predicted log Kow values ranging from 4.2 to 11.0.

Using the ECOSAR program (developed by the US Environmental Protection Agency’s Office of Chemical Safety and Pollution Prevention, v 1.11), the predicted effect levels for acute toxicity to fish exceeded the estimated water solubility of the chemical structures evaluated. In some cases toxic effects were predicted at concentrations 10-fold greater than the predicted water solubility limit. Thus, no acute effects at water saturation were predicted for the test material, and the study was deemed scientifically not necessary.

No acute effects at water saturation were predicted for the test material, therefore acute testing with fish is waived since the study is scientifically not necessary.

Key value for chemical safety assessment

Additional information