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EC number: 946-308-7
CAS number: -
To determine irritant and/or corrosive effects of a single 24 hr
exposure of the test substance on the intact skin and abraded skin of
A sample of cocamidopropyl PG-dimonium chloride was tested as received,
After acclimatation to the lab, six healthy New Zealand albino rabbits
were clipped free of haire over approximately 10% of their body surface.
Two test sites, each approximately 2.5cm2, were delineated. One was left
intact and one was abraded. 0.5 mL of the test material was placed on
each site and occluded for 24hrs. The patches were then removed and the
test sites were wiped to prevent further exposure. The test sites were
evaluated 24 and 72 hrs after initial exposure.
All animal appeared healthy and active. There were no sign of gross
toxicity, adverse pharmacologic effects, or abnormal behavior.
One rabbit exhibited a slight erythema at the abraded site 24 hrs after
dosing. This cleared by 72 hrs. No edema was observed at any time during
the test period.
Summary scores and individual skin scores are available in the study
The Primary Dermal Irritation Index (PDII) was 0.043.
Based on scoring system used, the material is classified as non-primary
skin irritant when applied as received, undiluted
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