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EC number: 908-998-8 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Feb 1966
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study design similar to OECD 401; summary report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- 7 days observation period, females tested
- GLP compliance:
- no
- Remarks:
- performed before GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- (propan-2-yloxy)phosphonic acid; phosphoric acid; propan-2-ol
- EC Number:
- 908-998-8
- Molecular formula:
- can not be determined for reaction masses
- IUPAC Name:
- (propan-2-yloxy)phosphonic acid; phosphoric acid; propan-2-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: 12 h
- Diet (e.g. ad libitum): Standard Altromin R (Altrogge, Lage/Lippe, Germany), ad libitum
- Water (e.g. ad libitum): tap water. ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- concentration in vehicle: 10 %
- Doses:
- Reinigerkomponente MI - normal:
1.6; 2.5; 4.0 or 6.3 mL/100 g bw - No. of animals per sex per dose:
- 10 females/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Statistics:
- no data
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3.85 other: mL (10% solution)/100 g
- 95% CL:
- > 3.75 - <= 4
- Mortality:
- Dose: 1.6 mL (10% solution)/100 g, Mortality rate: 0 / 10
Dose: 2.5 mL (10% solution)/100 g, Mortality rate: 0 / 10
Dose: 4.0 mL (10% solution)/100 g, Mortality rate: 7 / 10
Dose: 6.3 mL (10% solution)/100 g, Mortality rate: 10 / 10 - Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Conclusions:
- The median lethal dose of the testsubstance was 3.85 mL/100 g body weight.
- Executive summary:
The test item was tested for its acute oral toxicity potential. 10 female rats were treated with doses of 1.6, 2.5, 4.0 or 6.3 mL (10% solution)/100 g bw and observed for 7 days.
The median lethal dose was 3.78 mL (10% solution)/100 g bw.
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