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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Feb 1966
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study design similar to OECD 401; summary report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report date:
1966

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
7 days observation period, females tested
GLP compliance:
no
Remarks:
performed before GLP
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Reaction mass of isopropyl dihydrogen phosphate and phosphoric acid and propan-2-ol
EC Number:
908-998-8
Molecular formula:
can not be determined for reaction masses
IUPAC Name:
Reaction mass of isopropyl dihydrogen phosphate and phosphoric acid and propan-2-ol

Test animals

Species:
rat
Strain:
other: Albino
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Fasting period before study: 12 h
- Diet (e.g. ad libitum): Standard Altromin R (Altrogge, Lage/Lippe, Germany), ad libitum
- Water (e.g. ad libitum): tap water. ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
concentration in vehicle: 10 %
Doses:
Reinigerkomponente MI - normal:
1.6; 2.5; 4.0 or 6.3 mL/100 g bw

No. of animals per sex per dose:
10 females/dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
Statistics:
no data

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
3.85 other: mL (10% solution)/100 g
95% CL:
> 3.75 - <= 4
Mortality:
Dose: 1.6 mL (10% solution)/100 g, Mortality rate: 0 / 10
Dose: 2.5 mL (10% solution)/100 g, Mortality rate: 0 / 10
Dose: 4.0 mL (10% solution)/100 g, Mortality rate: 7 / 10
Dose: 6.3 mL (10% solution)/100 g, Mortality rate: 10 / 10
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Conclusions:
The median lethal dose of the testsubstance was 3.85 mL/100 g body weight.
Executive summary:

The test item was tested for its acute oral toxicity potential. 10 female rats were treated with doses of 1.6, 2.5, 4.0 or 6.3 mL (10% solution)/100 g bw and observed for 7 days.

The median lethal dose was 3.78 mL (10% solution)/100 g bw.