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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From May 31, 2016 to June 03, 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Principles of method if other than guideline:
Additional guideline: "REACH Guidance Document “Guidance on information requirements and chemical safety assessment Chapter R.7a: Endpoint specific guidance” from July 2015".
Type of method:
flask method
Specific details on test material used for the study:
Batch no. #120039110,
Composition: >95% Butyl carbamate; <5% n-Butanol,
Purity: 100 % as per definition of UVCB.
Key result
Water solubility:
24 450 mg/L
Conc. based on:
test mat. (dissolved fraction)
Remarks:
nominal concentration 50 – 150 g/L
Temp.:
20 °C
pH:
6

Results:

 Meas. Conc. Test Subs. (g/L)  Total mean (g/L)  Total std dev. (g/L), RSD (%)  Nominal Conc. Test Subst. (g/L) Dissolved part (%)
 22.95  24.45   1.01 (4.1%)  50.1  46
 23.89  24.45   1.01 (4.1%)  80.1  30
 24.26  24.45   1.01 (4.1%)  100.0  24
 24.90  24.45   1.01 (4.1%)  110.0  23
 24.77  24.45   1.01 (4.1%)  130.0  19
 25.95  24.45   1.01 (4.1%)  150.0  17

Temperature was measured with 20.0 ± 0.5 °C.

Conclusions:
Under the study conditions, the water solubility of the test substance was determined to be 24450.0 ± 1010.0 mg/mL at 20°C and pH 6.
Executive summary:

A study was conducted to determine the water solubility of the test substance, according to OECD guideline 105 and EU Method A.6 (Flask method). The solubility of the test substance in water was determined by measurement of dissolved organic carbon (DOC) concentrations in the membrane filtered test solutions using TOC analyser.

Based on results of preliminary test, six different loading rates ranging from 50 -150 g/L were chosen to study the effect of loading rate on the measured water solubility followed by sampling and DOC analysis after 24, 48, and 72h. No Tyndall effect (i.e. a laser beam was not scattered when transmitted through the liquid) could be observed indicating that no colloidal dispersed particles are present. As the relative standard deviation between the six determinations of the water solubility was low (4.1%), an exact value for the solubility of the test susbstance in water could be stated. Under the study conditions, the water solubility of the test substance was determined to be 24450.0 ± 1010.0 mg/mL at 20°C and pH 6 (Affolter, 2016).

Description of key information

The water solubility was determined according to OECD guideline 105 and EU Method A.6 (Flask method) (Affolter, 2016).

Key value for chemical safety assessment

Water solubility:
24 450 mg/L
at the temperature of:
20 °C

Additional information