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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1988
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract
Qualifier:
according to guideline
Guideline:
other: DIN 38412, Part 11
GLP compliance:
not specified
Analytical monitoring:
no
Vehicle:
not specified
Test organisms (species):
Daphnia magna
Water media type:
freshwater
Limit test:
no
Total exposure duration:
24 h
Reference substance (positive control):
not specified
Key result
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
24 h
Dose descriptor:
EC0
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
24 h
Dose descriptor:
EC100
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Validity criteria fulfilled:
not specified
Conclusions:
Under the study conditions, the nominal 24h EC50 of the test substance for Daphnia magna was determined to be > 1000 mg/L.
Executive summary:

A study was conducted to determine the short-term toxicity of the test substance (purity not given) to aquatic invertebrate according to DIN Method 38412, Part 11. No analytical dose verification was conducted. Under the study conditions, the nominal 24 h EC50 was determined to be >1000 mg/L (Voelskow, 1988).

Description of key information

The 48 h EC50 of the substance was determined to be >1000 mg/L (nominal; no information on purity).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
1 000 mg/L

Additional information

A study was conducted to determine the short-term toxicity of the test substance (butyl carbamate; purity not given) to aquatic invertebrate according to DIN Method 38412, Part 11. No analytical dose verification was conducted. Under the study conditions, the nominal 24 h EC50 was determined to be >1000 mg/L (Voelskow, 1988). No further details are available. However, these results can be supported by a acute toxicity study conducted with the read across substance, methyl cabramate in Daphnia magna. This study was conducted according to method given by U. S. Environmental Protection Agency (1975) and American Public Health Association (1980), in compliance with GLP. Based on the findings of a range finding test, ten Daphnia (less than 24 h old) per beaker were exposed to test substance concentration of 0, 100, 180, 320, 560 and 1,000 mg/L in duplicate for 48 h under static conditions. No analytical dose verification was conducted. Water quality parameters of temperature, dissolved oxygen and pH were measured at 0 and 48 h interval and they were found to be within acceptable limits. No abnormal effects such as mortality, surfacing or Daphnids lying on the bottom of test vessels were observed in any of the test concentrations during the test.Under the study conditions, the 48 h LC50 and NOEC for the read across substance was determined to be >1,000 and 1,000 mg/L, respectively (Forbis AD, 1986).