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EC number: 218-658-4 | CAS number: 2212-32-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20.03. - 17.04.1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 A (Ready Biodegradability: DOC Die Away Test)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- ISO 7827 (Evaluation in an Aqueous Medium of the "Ultimate" Aerobic Biodegradability of Organic Compounds - Method by Analysis of Dissolved Organic Carbon (DOC))
- Qualifier:
- according to guideline
- Guideline:
- other: EG-guideline 92/69/EWG
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Activated sludge from laboratory wastewater plants treating municipal and synthetic sewage
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 20 mg/L
- Based on:
- DOC
- Initial conc.:
- 35 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST SYSTEM
- Test vessel: 1 L-glass bottle
- Fill volume: 1000ml
- Aeration: yes
- No. of vessels test substance (replicates): 2
- No. of vessels blank control (replicates): 2
- No. of vessels reference substance (replicates): 1
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Test period: 28 days
- Incubation temperature: room temperature (approx. 20°C)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable):
DOC removal - Reference substance:
- aniline
- Parameter:
- % degradation (DOC removal)
- Value:
- 0
- Sampling time:
- 0 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 5
- Sampling time:
- 3 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 1
- Sampling time:
- 7 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 8
- Sampling time:
- 14 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 1
- Sampling time:
- 28 d
- Results with reference substance:
- Degradation of the reference substance anilline was 95% after 5 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Not readily biodegradable (according to OECD criteria)
- Executive summary:
A reliable, GLP compliant experimental aerobic ready biodegradability study was conducted according to EG-guideline 92/69/EWG (equivalent to the OECD 301A Guideline (ready biodegradability: DOC Die Away Test) and ISO 7827 method). There were no deviations from the test guideline and the validity criteria for testing of ready biodegradability according to OECD criteria were fulfilled.
The reference substance aniline showed 95% degradation (DOC removal) after 5 days, however only 1% degradation (DOC removal) of the test substance, 2-[[2-(dimethylamino)ethyl]methylamino]ethanol (CAS 2212-32-0), was shown after 28 days. It is therefore concluded that 2-[[2-(dimethylamino)ethyl]methylamino]ethanol is not readily biodegradable.
Reference
Summary of results – DOC decrease [%]:
Test duration [days] |
Reference substance |
Inhibition control |
Adsorption control |
TS 1 |
TS 2 |
TS mean value |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
2 |
-1 |
-7 |
-9 |
-3 |
-6 |
3 |
7 |
2 |
2 |
3 |
6 |
5 |
5 |
95 |
44 |
2 |
1 |
7 |
4 |
7 |
95 |
45 |
n.p. |
-1 |
2 |
1 |
10 |
91 |
47 |
n.p. |
-4 |
0 |
-2 |
14 |
94 |
46 |
n.p. |
4 |
11 |
8 |
17 |
93 |
43 |
n.p. |
-1 |
3 |
1 |
21 |
95 |
43 |
n.p. |
-14 |
-6 |
-10 |
24 |
88 |
45 |
n.p. |
-3 |
0 |
-2 |
27 |
96 |
43 |
n.p. |
-8 |
-1 |
-5 |
28 |
95 |
46 |
n.p. |
1 |
1 |
1 |
TS: Test substance
n.p.: no adsorption control performed
Description of key information
A reliable, GLP compliant experimental aerobic ready biodegradability study was conducted according to EG-guideline 92/69/EWG (equivalent to the OECD 301A Guideline (ready biodegradability: DOC Die Away Test) and ISO 7827 method). There were no deviations from the test guideline and the validity criteria for testing of ready biodegradability according to OECD criteria were fulfilled. The reference substance aniline showed 95% degradation (DOC removal) after 5 days, however only 1% degradation (DOC removal) of the test substance, 2-[[2-(dimethylamino)ethyl]methylamino]ethanol (CAS 2212-32-0), was shown after 28 days.
It is therefore concluded that 2-[[2-(dimethylamino)ethyl]methylamino]ethanol is not readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
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