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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 September 2017 to 02 November 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2008
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
100 g/L
Conc. based on:
test mat.
Remarks:
(tetrahydrate)
Temp.:
20 °C
pH:
5.6
Details on results:
Preliminary Test
- The estimate of the water solubility at 20.0 ± 0.5 °C was 27.9 gY/L, 83.6 g/L as equivalent anhydrous yttrium acetate and 106 g/L as equivalent yttrium acetate tetrahydrate. The pH of the solution was 5.9.
 
Definitive Test
- The counts per second relating to the standard and sample solutions are shown in Tables 1 and 2.
- Mean results at 20.0 ± 0.5°C:
As yttrium: 26.3 gY/L
As equivalent anhydrous yttrium acetate 78.7 g/L
As equivalent yttrium acetate tetrahydrate 100 g/L
 
Discussion
- On completion of the definitive test equilibration period, the samples had excess, undissolved test material present. After filtration, the samples were observed to be visually clear, colourless solutions with no definitive Tyndall beam effect.
- The yttrium (88.9 amu) concentrations were corrected to “as equivalent anhydrous yttrium acetate” (266.0 amu) and “as yttrium acetate tetrahydrate” (338.1 amu) using the masses shown in brackets.

Table 1: Counts per Second

Solution

Counts per Second

Yttrium

Internal Standard

Standard 1.00 mg/L

8841699.9

141497.6

Standard 2.50 mg/L

22318183.6

141826.7

Standard 5.01 mg/L

44122217.1

141110.7

Standard 10.01 mg/L

87575144.3

139761.7

Standard 10.01 mg/L

87850364.2

139825.2

Standard 15.02 mg/L

130385040.3

137505.2

Standard 20.02 mg/L

171071016.3

134927.9

Matrix blank

71262.4

135839.6

Sample 1A

96496754.1

135732.3

Sample 1B

96801305.2

136288.5

Sample 2A

78273639.9

135331.5

Sample 2B

90111975.3

136395.5

Sample 3A

94136250.8

136315.0

Sample 3B

86989153.1

137865.0

 

Table 2: Concentration of the test material in the sample solutions

Sample Number

 

Concentration (g/L)

Solution pH

As Yttrium

As Equivalent Anhydrous Yttrium Acetate

As Equivalent Yttrium Acetate Tetrahydrate

1

28.2

84.3

107

5.6

2

24.6

73.5

93.4

5.6

3

26.2

78.4

99.7

5.6

 

Conclusions:
Under the conditions of this study, the water solubility of the test material has been determined at 20.0 ± 0.5 °C to be 100 g/L based on the test material being yttrium acetate tetrahydrate.
Executive summary:

The water solubility of the test material was determined in accordance with the standardised guidelines OECD 105 and EU Method A.6, under GLP conditions.

The shake flask method was performed and the samples were analysed using inductively coupled plasma mass spectrometry (ICP-MS).

On completion of the definitive test equilibration period, the samples had excess, undissolved test material present. After filtration, the samples were observed to be visually clear, colourless solutions with no definitive Tyndall beam effect.

The mean results at 20.0 ± 0.5 °C were: as yttrium: 26.3 gY/L, as equivalent anhydrous yttrium acetate 78.7 g/L and as equivalent yttrium acetate tetrahydrate 100 g/L

Under the conditions of this study, the water solubility of the test material has been determined at 20.0 ± 0.5 °C to be 100 g/L based on the test material being yttrium acetate tetrahydrate.

Description of key information

Under the conditions of this study, the water solubility of the test material has been determined at 20.0 ± 0.5 °C to be 100 g/L based on the test material being yttrium acetate tetrahydrate.

Key value for chemical safety assessment

Water solubility:
100 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test material was determined in accordance with the standardised guidelines OECD 105 and EU Method A.6, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The shake flask method was performed and the samples were analysed using inductively coupled plasma mass spectrometry (ICP-MS).

On completion of the definitive test equilibration period, the samples had excess, undissolved test material present. After filtration, the samples were observed to be visually clear, colourless solutions with no definitive Tyndall beam effect.

The mean results at 20.0 ± 0.5 °C were: as yttrium: 26.3 gY/L, as equivalent anhydrous yttrium acetate 78.7 g/L and as equivalent yttrium acetate tetrahydrate 100 g/L

Under the conditions of this study, the water solubility of the test material has been determined at 20.0 ± 0.5 °C to be 100 g/L based on the test material being yttrium acetate tetrahydrate.