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EC number: 296-719-4
CAS number: 93028-28-5
A single four-hour whole-body inhalation
exposure was performed for Lubrizol Corporation using CD (Sprague-Dawley
derived) rats (5/sex) todetermine the acute inhalation toxicity of OS
80020 (product as manufactured diluted to 65% in mineral oil). The test
substance was administered into the breathing zone of the animals as an
aerosol on 8 October 1986.
Species and strain of the test animal,
method and route of test substance administration and target exposure
level were determined by the sponsor. The test procedures followed
guidelines described in the Health Effects Test Guidelines; Office of
Pesticides and Toxic Substances, United States Environmental Protection
Agency (EPA), October 1984 and in the Pesticide Assessment Guidelines,
Subdivision F; Hazard Evaluation: Human and DomesticAnimals; Office of
Pesticide Programs, United States Environmental Protection Agency,
Office of Pesticide and Toxic Substances, November 1982; Section 81 -3
"Acute Inhalation Toxicity Study". This study was conducted at
Bio/dynamics, Inc., Mettlers Road, East Millstone, New Jersey 08873.
A group of ten CD (Sprague-Dawley
Derived) train rats (five males and five females) was exposed to an
aerosol. The animals were exposed for four hours using a whole body
exposure system, followed by a fourteen day observation period.
mean achieved atmosphere concentration was as follows:
Mean Maximum Attainable (mg/L)
The characteristics of the achieved
atmosphere were as follows:
Mean Maximum Attainable Atmosphere Concentration (mg/L)
Mean Mass Median Aerodynamic Diameter (µm)
(% <10 µm)
Geometric Standard Deviation
The mortality data were summarised as
Observations noted during exposure included
reduced activity, closed eyes and a few animals with labored breathing
towards exposure completion. Signs exhibited by animals upon removal
from the chamber and during the two-hour post-exposure observation
period on Day 1 included secretory signs, some respiratory signs,
hunched appearance and matted coats. During Test Week 1, test animals
exhibited decreasing signs of treatment such as secretory signs and
matted coat. These signs mostly abated by Day 8 and during Test Week 2
animals exhibited few continuing signs of treatment.
Test Week 1 body weights were slightly less
than pretest values in some animals. This was considered a minimal
response to exposure. Test Week 2 body weights were considered
No gross effects
of the test material were observed.
of ten CD (Sprague-Dawley derived) r a t s receiving a single four-hour
exposure to 1.9 mg/l of OS 80020 as a maximum attainable respirable
aerosol, survived until sacrifice on Day 15. Signs of treatment included
reduced activity and labored breathing during the exposure. Signs of
treatment such as secretory signs and matted coats persisted during the
first week after exposure, but generally abated before the Day 15
sacrifice. A minimal, transient adverse effect upon body weight was
produced by treatment. Otherwise bodyweight values were considered
unremarkable. Gross post mortem observations were considered
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