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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Link to relevant study records
genetic toxicity in vitro
Type of information:
Adequacy of study:
supporting study
Study period:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The prediction was performed by a valid QSAR model and appears to be reliable as the substance is included in the applicability domain of the model.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
other: REACH guidance on QSARs R6, May 2008
Principles of method if other than guideline:
General model for estimating the mutagenicity.
Additional information on results:
Model assessment:
the prediction is considered as reliable considering the following issues:

- similar compounds with known experimental value in the training set have been found;
- the similar molecules found in the training set have experimental values that agree with the predicted value;
- the accuracy of prediction for similar molecules found in the training set is good;
- all atom centered fragment of the compound have been found in the compounds of the training set;
-descriptors for this compound have values inside the descriptor range of the compounds of the training set;
- no structural alert, that could be associated with genotoxic effects, has been found in the structure of the molecule.

Details are provided in attachment on the section: "attached full study report".
Interpretation of results (migrated information):

According to this prediction, the substance should not have genotoxic activity.
Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Additional information from genetic toxicity in vitro:

Predicted data from QSAR models show that the substance is NON-Mutagen. Predicted substance is into the Applicability Domain of the model. This information is inconclusive for the classification.

Justification for selection of genetic toxicity endpoint
Predicted data from QSAR models show that the substance is NON-Mutagen.

Justification for classification or non-classification

According to Directive 67/548/EEC and to Regulation (EC) n. 1272/2008, the substance should not be classified for mutagenicity because the data are inconclusive.