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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 December 2016 - 29 March 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
dynamic method
Remarks:
Vapour-liquid equilibrium

Test material

Constituent 1
Chemical structure
Reference substance name:
Adenosine 5'-(tetrahydrogen triphosphate), disodium salt
EC Number:
213-579-1
EC Name:
Adenosine 5'-(tetrahydrogen triphosphate), disodium salt
Cas Number:
987-65-5
Molecular formula:
C10H14N5O13P3.2Na
IUPAC Name:
disodium 9-{5-O-[hydroxy({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphoryl]pentofuranosyl}-9H-purin-6-amine
impurity 1
Chemical structure
Reference substance name:
Water
EC Number:
231-791-2
EC Name:
Water
Cas Number:
7732-18-5
Molecular formula:
H2O
IUPAC Name:
Oxidane
impurity 2
Reference substance name:
Unknown impurities.
Molecular formula:
Not available as unknown impurities.
IUPAC Name:
Unknown impurities.
Test material form:
solid: crystalline
Details on test material:
Storage conditions: 2-8°C
Batch No: 11678500

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
< 0.1 Pa
Remarks on result:
other: calculated by extrapolation
Key result
Temp.:
25 °C
Vapour pressure:
< 0.1 Pa
Remarks on result:
other: calculated by extrapolation
Key result
Temp.:
50 °C
Vapour pressure:
< 0.1 Pa
Remarks on result:
other: calculated by extrapolation

Any other information on results incl. tables

In the first measurement with the vapour pressure balance, the vapour pressure was measured in the temperature range of 18 to 24 °C. Since no evaluable vapour pressure curve could be determined. Further tests were carried out using the Knudsen cell apparatus. Due to the fact that no evaluable vapour pressure curve could be recorded using the Knudsen cell method, a second measurement was performed with the vapour pressure balance in the temperature range of 28 – 118 °C. The measured vapour pressure values of the second measurement with the measured temperature are provided in the section "Overal remarks".

Due to the fact that the test item showed no proper linear correlation of the vapour pressure and the inverse temperature 1/T, the Antoine constants could not be evaluated in the measured temperature range.Due to this result, the vapour pressure for the temperatures 20, 25 and 50 °C was estimated on the basis of the maximum measured vapourpressures of 1.06 × 10-1 Pa at temperatures of 73 and 78 °C.

Applicant's summary and conclusion

Conclusions:
The test item ATP, Di-Na (CAS no. 987-65-5) showed no evaluable vapour pressure curve in the temperature range of 10 to 118 °C. Due to this result, the vapour pressure for the temperatures 20, 25 and 50 °C is estimated on the basis of the maximum vapour pressures measured of the second measurement using the vapour pressure balance, according to Regulation EC No. 440/2008 Method A.4. Vapour Pressure and OECD Test Guideline 104 (2006). The vapour pressure of the test item was estimated to be < 0.1 Pa at 20°C, 25°C and 50°C.
Executive summary:

The test item ATP, Di-Na (CAS no. 987-65-5) showed no evaluable vapour pressure curve in the temperature range of 10 to 118 °C. Due to this result, the vapour pressure for the temperatures 20, 25 and 50 °C is estimated on the basis of the maximum vapour pressures measured of the second measurement using the vapour pressure balance, according to Regulation EC No. 440/2008 Method A.4. Vapour Pressure and OECD Test Guideline 104 (2006). The vapour pressure of the test item was estimated to be < 0.1 Pa at 20°C, 25°C and 50°C.