Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-525-1 | CAS number: 658-79-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- Triplicate samples (3 x 2 x ~5 mL) were taken at the beginning of the test from the test solution, then 2 x ~5 mL sample was taken from each replicate at the end of the experiment. Samples from the control were taken at the start and end of the experiment (1 x 2 x ~5 mL).
Test item solutions were sampled after the preparation and were stored in freezer until measurement. - Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Species and strain: Daphnia magna (Straus)
- Age at study initiation (mean and range, SD): Less than 24 h old at the beginning of the test.
- Source: Hungarian University of Agriculture and Life Sciences, Department of Aquaculture 2100 Gödöllő, Páter Károly u. 1. – Hungary
- Feeding during test: no
ACCLIMATION
To avoid the necessity of adaptation prior to the test, the water used in the test was similar to the culture conditions (water temperature, background colour, light intensities).
- Type and amount of food: The Daphnia were fed with concentrated algal suspension of Raphidocelis subcapitata during the holding and were not fed during the test. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 231 mg/L (as CaCO3)
- Test temperature:
- 21.2 - 21.9°C
- pH:
- 7.39 – 7.75
- Dissolved oxygen:
- 8.3 – 8.9 mg/L
- Nominal and measured concentrations:
- nominal: 100 mg/L
measured geometric mean: 102.3 mg/L - Details on test conditions:
TEST SYSTEM
- Volume of solution: 40 ml/flask
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Reconstituted water (ISO medium, according to OECD 202)
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16-hour light and 8-hour dark cycle
RANGE-FINDING STUDY
- Test concentrations: 0.1, 1, 10, 100 mg/l
- Results used to determine the conditions for the definitive study: yes, no significant immobilisation => limit test- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate is tested at least twice a year to demonstrate satisfactory test conditions. The date of the last study (Study Code: 22/137-023DA) with reference item Potassium dichromate (batch no.: A0430787) is: 24 - 25 June 2022.
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 115 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- 24h EC50: 0.63 mg/L, (95 % confidence limits: 0.52 – 0.76 mg/L).
This result falls within the acceptable range (0.6 mg/L to 2.1 mg/L) hence this reference study shows that the acute immobilization test on Daphnia magna is valid in this laboratory. - Validity criteria fulfilled:
- yes
- Conclusions:
- There were no immobilized animals in the test item treated group and in the control group.
Under the conditions of this Daphnia magna acute immobilisation study the observed 48h EC50 for N-Glycyl-L-tyrosine dihydrate is > 115 mg/L corresponding to a 48h EC50 of > 100 mg/L for the active ingredient N-Glycyl-L-tyrosine.
Reference
No abnormal behaviour or appearance of test animals was detected.
Description of key information
Short-term toxicity to aquatic invertebrates: EC50 (48 h): > 100 mg/L (nominal, OECD202)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.