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Physical & Chemical properties

Particle size distribution (Granulometry)

Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
17 July 2017 - 11 August 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Version / remarks:
1981
Deviations:
no
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Version / remarks:
2009
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
Laser scattering/diffraction
Type of distribution:
volumetric distribution

Test material

Constituent 1
Chemical structure
Reference substance name:
Disodium β-glycerophosphate
EC Number:
212-464-3
EC Name:
Disodium β-glycerophosphate
Cas Number:
819-83-0
Molecular formula:
C3H7O6P.2Na
IUPAC Name:
disodium β-glycerophosphate
impurity 1
Chemical structure
Reference substance name:
Disodium α-glycerophosphate
EC Number:
216-304-3
EC Name:
Disodium α-glycerophosphate
Cas Number:
1555-56-2
Molecular formula:
C3H9O6P.2Na
IUPAC Name:
disodium 2,3-dihydroxypropyl phosphate
impurity 2
Chemical structure
Reference substance name:
Water
EC Number:
231-791-2
EC Name:
Water
Cas Number:
7732-18-5
Molecular formula:
H2O
IUPAC Name:
Oxidane
Test material form:
solid: particulate/powder
Details on test material:
Batch No.: 11769400
Storage: 15-25°C
Specific details on test material used for the study:
Since the test item contains no lager particles, sieving < 2000 µm was not necessary and the test item was used as delivered.

Results and discussion

Particle sizeopen allclose all
Key result
Percentile:
D10
Mean:
5.1 µm
St. dev.:
0.01
Remarks on result:
other: mean of two test series (5.1 µm; 5.1 µm)
Key result
Percentile:
D50
Mean:
24.1 µm
St. dev.:
0.08
Remarks on result:
other: mean of two test series (24.0 µm; 24.2 µm)
Key result
Percentile:
D90
Mean:
70.1 µm
St. dev.:
0.04
Remarks on result:
other: mean of two test series (70.0 µm; 70.1 µm)

Any other information on results incl. tables

Visual Microscope Analysis

(1) under a microscope with 5x magnification agglomerates can be observed,

(2) under a microscope with 20x magnification magnification the test item consists mostly of cylindrical particles at lower particle sizes,

(3) under a microscope with 50x magnification the test item consists mostly of cylindrical particles at lower particle sizes.

Particle size distribution

The test item shows a unimodal particle size distribution with one peak at approx. 20 µm.

Test series 1:

 Percentile  Particle size (µm)  Standard deviation
 D10  5.1  0.06
 D50  24.2  0.14
 D90  70.1 0.33

Test series 2:

 Percentile  Particle size (µm)  Standard deviation
 D10  5.1  0.12
 D50  24.0  0.27
 D90  70.0 0.75

Applicant's summary and conclusion

Conclusions:
The test item Disodium beta-glycerophosphate (CAS no. 819-83-0) has a median particle size D50 = 24.1 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Guideline OPPTS 830.7520 (1996).
Executive summary:

The test item Disodium beta-glycerophosphate (CAS no. 819-83-0) has a median particle size D50= 24.1 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Guideline OPPTS 830.7520 (1996).