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Administrative data

Endpoint:
acute toxicity: other routes
Remarks:
route not specified, presumed intravenous
Type of information:
other: information reported on a patent record
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
other: Patent record
Title:
Offenlegunsschrift 25 02 735 Infusionslösungen mit Salzen des Glycerophosphats
Year:
1976

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Disodium β-glycerophosphate
EC Number:
212-464-3
EC Name:
Disodium β-glycerophosphate
Cas Number:
819-83-0
Molecular formula:
C3H7O6P.2Na
IUPAC Name:
disodium 2,3-dihydroxypropyl phosphate
Test material form:
not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
unspecified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 400 mg/kg bw

Applicant's summary and conclusion

Conclusions:
An acute toxicity test on rats was performed to determine the safety of using glycerophosphate salt for IV solutions (administration type not specified, but it could be presumed it was IV).
Beta-Glycerophosphate (CAS 819-83-0) is not toxic to rats. The LD50 was determined to be 3400 mg/kg bw for rats.
Executive summary:

An acute toxicity test on rats was performed to determine the safety of using glycerophosphate salt for IV solutions (administration type not specified, but it could be presumed it was IV)

Beta-Glycerophosphate (CAS 819-83-0) is not toxic to rats. The LD50 was determined to be 3400 mg/kg bw for rats.

Alpha-Glycerophosphate was also tested. The LD50 was determined to be 3800 mg/kg bw in rats.

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