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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May 2012 to November 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
gas chromatography
Key result
Type:
log Pow
Partition coefficient:
2.86
Temp.:
20.4 °C
pH:
5.2
Conclusions:
The partition coefficient of the test item has been determined to be 723 at 20.4 +/- 0.5 degrees Celsius, Log Pow iof 2.86.
Executive summary:

The determination of partition coefficient was performed using the shake-flask method. This was due to the expected partition coefficient obtained in the prelimnary assessment. The n-octanol saturated water was pH unadjusted as the test item contained no dissociating groups within the environmentally relevant pH range.

Description of key information

The Partition Coefficient was determined to be 2.89 at 20.4 +/- 0.5°C using the shake-flask method.

Key value for chemical safety assessment

Log Kow (Log Pow):
2.86
at the temperature of:
20.4 °C

Additional information