Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1981
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Justification for type of information:
This study was conducted in the early days of GLP and prior to guidelines, but was done at a highly reputible laboratory. So extensive details are missing, but there is no reason to question the quality and the results

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Version / remarks:
At this time, studies conducted at the Kodak laboratory used an in-house protocol similar to OECD 401
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[(2-ethylhexyl)oxy]ethanol
EC Number:
216-323-7
EC Name:
2-[(2-ethylhexyl)oxy]ethanol
Cas Number:
1559-35-9
Molecular formula:
C10H22O2
IUPAC Name:
2-[(2-ethylhexyl)oxy]ethan-1-ol
Specific details on test material used for the study:
No description is available. The standard method was to test the substance as marketed at the time

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
not specified
Details on test animals or test system and environmental conditions:
None given

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
Not provided
Doses:
Not provided
No. of animals per sex per dose:
Not provided
Control animals:
not specified
Details on study design:
Not provided

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
4 674 mg/kg bw
Based on:
test mat.
Remarks on result:
other: fasted rats
Sex:
male
Dose descriptor:
LD50
Effect level:
8 169 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Fed animals
Clinical signs:
other: slight to severe weakness, inactivity, depression, prostration, labored breathing, anorexia, reddish deposit around eyes, nose and mouth and death.
Gross pathology:
Not provided

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria