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Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Study duration:
subchronic
Species:
rat
Quality of whole database:
Klimisch 1
Effect on fertility: via inhalation route
Endpoint conclusion:
no study available
Effect on fertility: via dermal route
Endpoint conclusion:
no study available
Additional information

IMB is of low toxicity in acute toxicity in an acute oral study. A reproductive toxicity screening study is available for the closely related analogue, EMB, which showed no evidence of effects on fertility (NOAEL 1000mg/kg bw/day). Therefore, additional animal studies to investigate potential reproduction toxicity are not scientifically justified.

Effects on developmental toxicity

Description of key information

No effects seen.

Link to relevant study records
Reference
Endpoint:
developmental toxicity
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Reason / purpose for cross-reference:
read-across source
Effect on developmental toxicity: via oral route
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Study duration:
subchronic
Species:
rat
Quality of whole database:
Klimisch 1
Effect on developmental toxicity: via inhalation route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via dermal route
Endpoint conclusion:
no study available

Toxicity to reproduction: other studies

Description of key information

Ne effects observed

Additional information

IMB is of low toxicity in acute toxicity in an acute oral study. A reproductive toxicity screening study is available for the closely related analogue, EMB, which showed no evidence of effects on fertility (NOAEL 1000mg/kg bw/day). Therefore, additional animal studies to investigate potential reproduction toxicity are not scientifically justified.

Justification for classification or non-classification

A 54 day repeat dose study with reproductive / developmental toxicity screening with the read-across substance EMB showed no toxicity. IMB shows no toxicity in any other studies. Consequently this substance will not be classified as toxic to reproduction.

Additional information