Registration Dossier
Registration Dossier
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EC number: 208-728-2 | CAS number: 539-88-8
Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Ecotoxicity studies of the levulinate ester series
- Author:
- Lomba L, Muñiz, S., Pino M., Navarro, E. and Giner, B.
- Year:
- 2 014
- Bibliographic source:
- Ecotoxicology (2014) 23:1484–1493
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: UNE-EN-ISO 11348-3 (2007) Water quality: determination of the inhibitory effect of water samples on the light emission of Vibrio fischeri (Luminescent bacteria test)
- GLP compliance:
- no
- Remarks:
- Published data, no information available on GLP Compliance
- Type of study / information:
- Determination of the inhibitory effect of water samples on the light emission of Vibrio fischeri (Luminescent bacteria test).
Test material
- Reference substance name:
- Ethyl 4-oxovalerate
- EC Number:
- 208-728-2
- EC Name:
- Ethyl 4-oxovalerate
- Cas Number:
- 539-88-8
- Molecular formula:
- C7H12O3
- IUPAC Name:
- ethyl 4-oxopentanoate
Constituent 1
Results and discussion
Any other information on results incl. tables
EC50 (30 min) = 182 ± 5 mg/l.
Applicant's summary and conclusion
- Conclusions:
- EC50 (30 min) = 182 ± 5 mg/l.
- Executive summary:
The inhibition of bioluminescence of Vibrio fischeri bacteria was assessed according to the UNE-EN-ISO 11348-3. The lyophilized V. fischeri were exposed to several dilutions for each of the chemical were prepared using a 2 % NaCl stock solution. The different concentrations ranges assessed for this bioassay were 0–900 mg/l.
The solution equilibrated for 10 min at 15 °C, and subsequently, the first measurements were taken to obtain the initial luminescence; then 0.5 ml of each dilution to be tested was added to the cuvette. The inhibition of luminescence was measured after 30 min.
EC50 (30 min) = 182 ± 5 mg/l.
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