Registration Dossier
Registration Dossier
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EC number: 210-194-0 | CAS number: 609-65-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: CFR, Title 16, Section 1500.41
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-chlorobenzoyl chloride
- EC Number:
- 210-194-0
- EC Name:
- 2-chlorobenzoyl chloride
- Cas Number:
- 609-65-4
- Molecular formula:
- C7H4Cl2O
- IUPAC Name:
- 2-chlorobenzoyl chloride
- Test material form:
- other: Liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other:
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Because of severe corrosion 4 of 6 Animals had to be sacrified.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Because of severe corrosion of the skin, 4 animals had to be killed. The substance therefore must be classified as corrosive.
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