Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vitro cytogenicity / chromosome aberration study in mammalian cells
Remarks:
Type of genotoxicity: chromosome aberration
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chlorobenzoyl chloride
EC Number:
210-194-0
EC Name:
2-chlorobenzoyl chloride
Cas Number:
609-65-4
Molecular formula:
C7H4Cl2O
IUPAC Name:
2-chlorobenzoyl chloride
Test material form:
other: liquid light yellow
Details on test material:
purity: 99%

Method

Species / strain
Species / strain / cell type:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Metabolic activation:
with and without
Test concentrations with justification for top dose:
0.4, 0.1, 0.02, 0.004, 0.0008 µl per plate with metabolic activation 0.3, 0.1, 0.02, 0.004, 0.0008 µl per plate with metabolic activation

Results and discussion

Applicant's summary and conclusion

Conclusions:
According to the study the testing substance 2-Chlorbenzoyl Chloride is not mutagenic.