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EC number: 600-809-4 | CAS number: 1072-53-3
Clinical signs and mortality
All tested animals showed no significant clinical signs and mortality during the experimental period.
Body weight changes
All tested animals showed no significant body weight changes concerned with test substance during the experimental period.
Observations of applied site
The test substance 24 hours after removal of challenge patch, 9 heads of animals showed discrete or patchy erythema, 7 heads of animals showed moderate and confluent erythema .
48 hours after removal of challenge patch, 9 heads of animals showed discrete or patchy erythema and 7 heads of animals showed moderate and confluent erythema .
24 hours and 48 hours after removal of challenge patch, no animal showed any other skin sensitisation reaction.
Determination of skin sensitisation
Final sensitisation rate of test substance was 80 % at 24 hours and 48 hours.
Final sensitisation rate of negative control was 0 % at 24 hours and 48 hours.
This study was performed to evaluate the skin sensitisation of ESA in 20 male guinea pigs. Induction and challenge were conducted at dose of 12.5 % (w/v), and then the skin reaction was evaluated at 24 & 48 hours after removal of challenge patch.
(1) All animals were not shown clinical signs and mortalities concerned with test substance during the experimental period.
(2) All animals were not shown body weight changes concerned with test substance during the experimental period.
(3) In treated group, sensitisation rate was determined as 80 % at 24 & 48 hours after challenge exposure.
Based on the results of the skin sensitisation study of ESA to male guinea pig, the sensitisation rate was determined as 80 %.
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