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EC number: 202-795-1
CAS number: 99-86-5
Table 1: Body weight and weight gain in grams
The acute dermal toxicity of the test item was studied according to OECD
Guideline 402 (GLP study). 3 female Sprague-Dawley rats were tested for
a exposure period of 24 h. Initially, a range finding study was
conducted at a single dose of 2000 mg/kg bw in one animal. Based on the
results of range finding two additional rats were tested at a dose of
2000 mg/kg bw. No mortality was observed. The body weight
evolution of the animals remained normal during the study. Erythema
was noted in treated animals (3/3) between days 1 and 7. This reaction
was associated with dryness of the skin (3/3) between days 3 and 12 and
scab (3/3) between days 3 and 8. The skin recovered a normal aspect at
day 13. No other clinical signs were observed. The macroscopic
examination of the animals at the end of the study did not reveal
treatment related effects. Based on these results, the test item
was found to be non toxic, with an LD50 > 2000 mg/kg bw.
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