Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1976-Dec-20 - 1976-Dec-23
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Version / remarks:
Federal Register Vol. 38, Nr. 187, page 27019, year 1973
GLP compliance:
no

Test material

Specific details on test material used for the study:
Colourless crystalline material.

Test animals

Species:
rabbit
Strain:
Himalayan
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: HOECHST AG
- Weight at study initiation: 1.5 - 2.0 kg
- Housing: individually
- Diet: ERKA 8300 (Futtermittelwerke Robert Koch oHG/Hamm), ad libitum
- Water: ad libitum

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
500 mg per patch
Duration of treatment / exposure:
24 hours
Observation period:
72 hours
Number of animals:
6
Details on study design:
Area of exposure: 6.25 cm²

Results and discussion

In vivo

Irritant / corrosive response data:
The score according to Federal Register Vol. 38, Nr. 187, page 27019, year 1973, §1500.41 was found to be 7.8 (severely irritant).

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
Based on the results of this study 1,2-Bis(chloromethyl)benzene is severely irritant to the skin.