Registration Dossier
Registration Dossier
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EC number: 210-291-8 | CAS number: 612-12-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1976-Dec-20 - 1976-Dec-23
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Version / remarks:
- Federal Register Vol. 38, Nr. 187, page 27019, year 1973
- GLP compliance:
- no
Test material
- Specific details on test material used for the study:
- Colourless crystalline material.
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG
- Weight at study initiation: 1.5 - 2.0 kg
- Housing: individually
- Diet: ERKA 8300 (Futtermittelwerke Robert Koch oHG/Hamm), ad libitum
- Water: ad libitum
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 500 mg per patch
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- Area of exposure: 6.25 cm²
Results and discussion
In vivo
- Irritant / corrosive response data:
- The score according to Federal Register Vol. 38, Nr. 187, page 27019, year 1973, §1500.41 was found to be 7.8 (severely irritant).
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Based on the results of this study 1,2-Bis(chloromethyl)benzene is severely irritant to the skin.
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