1,2-bis(chloromethyl)benzene

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

other information

Study period:

1976-Dec-20 - 1976-Dec-23

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other:

Version / remarks:

Federal Register Vol. 38, Nr. 187, page 27019, year 1973

GLP compliance:

no

Test material

Test material information

Specific details on test material used for the study:

Colourless crystalline material.

Test animals

Species:

rabbit

Strain:

Himalayan

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: HOECHST AG
- Weight at study initiation: 1.5 - 2.0 kg
- Housing: individually
- Diet: ERKA 8300 (Futtermittelwerke Robert Koch oHG/Hamm), ad libitum
- Water: ad libitum

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Amount / concentration applied:

500 mg per patch

Duration of treatment / exposure:

24 hours

Observation period:

72 hours

Number of animals:

6

Details on study design:

Area of exposure: 6.25 cm²

Results and discussion

In vivo

Irritant / corrosive response data:

The score according to Federal Register Vol. 38, Nr. 187, page 27019, year 1973, §1500.41 was found to be 7.8 (severely irritant).

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritant) based on GHS criteria

Conclusions:

Based on the results of this study 1,2-Bis(chloromethyl)benzene is severely irritant to the skin.