Registration Dossier
Registration Dossier
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EC number: 947-659-9 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Based on the data for the individual components (N-glycyl-L-tyrosine and potassium chloride) it can be concluded that the 72h EC50 for the reaction mass of N-glycyl-L-tyrosine hydrochloride and potassium chloride is above 100 mg/L.Key value for chemical safety assessment
Additional information
No data is available for the reaction mass of N-glycyl-L-tyrosine hydrochloride and potassium chloride on the toxicity to aquatic algae and cyanobacteria.
The substance consists mainly of the dipeptide N-glycyl-L-tyrosine hydrochloride (~39%), the ion potassium (~27%) , and chloride (~31%). Besides these two main components only non-hazardous / non-classified amino acids/peptides in small amounts are present (e.g. glycine ~3%),. Based on the composition of the substance it can be assumed that the results obtained with the individual main components (N-glycyl-L-tyrosine and potassium chloride) apply likewise to the test material under investigation (reaction mass of N-glycyl-L-tyrosine hydrochloride and potassium chloride). Therefore read-across data for the dipeptide N-glycyl-L-tyrosine and the salt potassium chloride is provided.
Toxicity of potassium chloride to aquatic algae and cyanobacteria was determined with Scenedesmus subspicatus according to OECD 201/EU Method C.3 and was determined as 72 h-EC50 > 100 mg/L and a NOEC >= 100 mg/L, both derived from growth rate (Neuhahn, 2010).
According to Annex XI section 1 of Regulation (EC) No 1907/2006 the performance of an immobilisation test in Daphnia magna (OECD) or an algal growth inhibition test is not required for N-glycyl-L-tyrosine because there is sufficient information about the physico-chemical properties of N-glycyl-L-tyrosine and its effects on human health and the environment. Further, according to a reliable QSAR prediction toxic effects occur significantly above the limit dose of 100 mg/L in daphnia, fish and algae.
Therefore, based on the data for the individual main components it can be assumed that the 72h EC50 for the reaction mass of N-glycyl-L-tyrosine hydrochloride and potassium chloride is above 100 mg/L.
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