Registration Dossier
Registration Dossier
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EC number: 947-662-5 | CAS number: -
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report. Test item compostion unknown
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Reaction Products of Naphthalene-1,6-diol with 2-Benzofuran-1,3-dione, sodium salt
- EC Number:
- 947-662-5
- Molecular formula:
- C28H14Na2O5
- IUPAC Name:
- Reaction Products of Naphthalene-1,6-diol with 2-Benzofuran-1,3-dione, sodium salt
- Test material form:
- solid
- Details on test material:
- Name of the test substance used in the study report: Scheckfarbstoff AS
The purity is stated as 100% of the drawn chemical structure in the order sheet. (Chemical structure is identical to the main component of the UVCB, CAS 6359-10-9)
The substance is stated to be a sales product.
The water solubility is indicated to be 20g/L. No information on pH is provided.
Constituent 1
- Specific details on test material used for the study:
- Name of the test substance used in the study report: Scheckfarbstoff AS
Content: 100%
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weight: males 28.4 g, females 26.0 g
The animals were offered a standardized animal laboratory diet.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- 0.5% aqueous CMC preparation
Form of application: suspension
Concentrations used: 2, 5.62, 7, 14.7 and 20% (w/v) - Doses:
- 200, 562, 700, 2470 and 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 900 mg/kg bw
- Mortality:
- 200 mg/kg: no deaths; 562 mg/kg: 1/5 males after 14 days; 700 mg/kg: 1/5 females and 2/5 males after 14 days; 1470 mg/kg: 4/5 females and 5/5 males after 14 days; 2000 mg/kg: all animals died within 24 hours
- Clinical signs:
- Protracted death, poor general state and weight loss; staggering, trembling, twitching, spastic gait, in some animals convulsions
- Gross pathology:
- Animals that died: intra-abdominal stain
Sacrificed animals: very fine intra-abdominal deposits of the test substance
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
