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Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-08-22
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
2008
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
2017-02-28
Type of method:
differential scanning calorimetry
Melting / freezing pt.:
194.4 °C
Atm. press.:
1 008 hPa
Decomposition:
yes
Decomp. temp.:
300 °C
Sublimation:
no

In the temperature range of 180 °C – 210 °C an endothermic effect (melting) was observed. No further endothermic effects was observed up to the decomposition of the test item in the temperature range of 300 °C – 350 °C, with a mean decomposition energy of approx. 180 J/g. No further thermic effects could be observed up to the maximum measured temperature of 500 °C.

Results of the DSC-measurements

No.

Sample weight / mg

Onset of Effect / °C

Range of effect / °C

Weight loss / mg

Atmospheric pressure / hPa

1

9.18

194.65
---

180 – 210 (endo)
300 – 350 (exo)

4.27

1007.5

2

10.45

194.10
---

180 – 210 (endo)
300 – 340 (exo)

5.15

1007.5

During the heating phase a distinct endothermic effect was observed in the temperature range of 180 – 210 °C, which can be assigned to the melting of the test item. As the onset temperatures in both tests do deviate by less than 0.5 K from their mean value of 194.38 °C, this temperature can be used as melting point. The test item has a melting point of 194.4 °C.

Since no further endothermic effects could be observed up to the decomposition of the test item started at 300 °C, it can be stated that the test item has no boiling point up to its decomposition.

Conclusions:
The test item N-[2-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]naphthalene-2-sulphonamide has a melting point of 194.4 °C at atmospheric pressure (1008 hPa) as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).

Description of key information

The test item N-[2-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]naphthalene-2-sulphonamide has a melting point of 194.4 °C at atmospheric pressure (1008 hPa) as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
194.4 °C

Additional information

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