1,1'-(4-methyl-1,3-phenylene)bis-1H-pyrrole-2,5-dione

Endpoint summary

Description of key information

Hydrolysis:

- OECD gudieline 111 study, GLP, moderate to fast hydrolysis in dependence of pH

Biodegradation:

- OECD guideline 301B study, GLP: not readily biodegradable, degradation was not > 60% within a 10-day window after achieving 10% degradation (day 14: 8% degradation ; day 28: 17 % degradation).

Transport and distribution

- Adsorption/desorption: log Koc(estimated from logKow): 0.8743 at 25°C, log Koc (estimated from MCI): 2:7051 at 25°C, QSAR estimation using EPISuiteTM Software/ KOCWIN v.2.00.

- Henry´s Law constant: 1.39E-11 Pa-m³/mol at 25°C, value obtainbed from the SRC database, the reported values are based on a QSAR prediction performed with anadequate QSAR model.

Additional information

Hydrolysis:

In a study conducted according to OECD guideline 111 (2004), 30 mg/L of the test substance 2,4 -Bismaleimidotoluene were dissolved in three buffers, pH 4, 7 and 9 and incubated at different temperatures (5, 10, 20, 30, and 50°C). The test item showed a moderate hydrolysis rate (2.4 h ≤ t1/2 ≤ 30 d) for pH 4 at 20 and 30 °C as well as for pH 7 at 20 °C and a fast hydrolysis rate (t1/2 ≤ 2.4 h) for the remaining test conditions (pH 4 at 50 °C, pH 7 at 30 and 50 °C as well as for pH 9 at 5, 10 and 20°C), with the higher half-lives at acidic conditions. Major transformation products were observed at all pH values and temperatures.

Biodegradation:

The test item was not readily biodegradable under the conditions of the Modified Sturm Test presently performed. Degradation failed to reach 60% within a 10-day window after achieving 10% degradation (day 14: 8% degradation ; day 28: 17 % degradation).

Adsorption/desorption:

According to the available data obtained from QSAR estimation, the soil sorption coefficient Koc for the test item was determined to be in the range between 7.487 L/kg and 507.1 L/kg and 95. According to the classification of Blume & Ahlsdorf, 2,4 -Bismaleimidotoluene can be regarded as a substance with either low or high binding strength to organic matter of soil and sediments based on these results. However, currently there is no defined, universally accepted applicability domain but according to the model description estimation of loc Koc from log Kow is more reliable due to interim measured log Kow from training set substances which substantiates the applicability of the model used. However, due to missing information about the applicability of the model with respect to the substance under investigation the results and the conclusions thereoff should be treated with care.

Henry´s Law constant:

The value obtained from the SRC database is based on a QSAR prediction performed. The QSAR prediction was made using EPISuiteTM HenryWin (model) and revealed a value of 1.39E-11 Pa-m³/mol at 25°C.

References: Blume, H. P., & Ahlsdorf, B. (1993). Prediction of pesticide behavior in soil by means of simple field tests.Ecotoxicology and environmental safety,26(3), 313-332.