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EC number: 229-175-3
CAS number: 6422-83-9
- OECD gudieline 111 study, GLP, moderate to
fast hydrolysis in dependence of pH
- OECD guideline 301B study, GLP: not
readily biodegradable, degradation was not > 60% within a 10-day window
after achieving 10% degradation (day 14: 8% degradation ; day 28: 17 %
Transport and distribution
- Adsorption/desorption: log Koc(estimated
from logKow): 0.8743 at 25°C, log Koc (estimated from MCI): 2:7051 at
25°C, QSAR estimation using EPISuiteTM Software/ KOCWIN v.2.00.
- Henry´s Law constant: 1.39E-11 Pa-m³/mol
at 25°C, value obtainbed from the SRC database, the reported values are
based on a QSAR prediction performed with anadequate QSAR model.
In a study conducted according to OECD
guideline 111 (2004), 30 mg/L of the test substance 2,4
-Bismaleimidotoluene were dissolved in three buffers, pH 4, 7 and 9 and
incubated at different temperatures (5, 10, 20, 30, and 50°C). The test
item showed a moderate hydrolysis rate (2.4 h ≤ t1/2 ≤ 30 d) for pH 4 at
20 and 30 °C as well as for pH 7 at 20 °C and a fast hydrolysis rate
(t1/2 ≤ 2.4 h) for the remaining test conditions (pH 4 at 50 °C, pH 7 at
30 and 50 °C as well as for pH 9 at 5, 10 and 20°C), with the higher
half-lives at acidic conditions. Major transformation products were
observed at all pH values and temperatures.
The test item was not readily biodegradable
under the conditions of the Modified Sturm Test presently performed.
Degradation failed to reach 60% within a 10-day window after achieving
10% degradation (day 14: 8% degradation ; day 28: 17 % degradation).
According to the available data obtained
from QSAR estimation, the soil sorption coefficient Koc for the test
item was determined to be in the range between 7.487 L/kg and 507.1 L/kg
and 95. According to the classification of Blume & Ahlsdorf, 2,4
-Bismaleimidotoluene can be regarded as a substance with either low or
high binding strength to organic matter of soil and sediments based on
these results. However, currently there is no defined, universally
accepted applicability domain but according to the model description
estimation of loc Koc from log Kow is more reliable due to interim
measured log Kow from training set substances which substantiates the
applicability of the model used. However, due to missing information
about the applicability of the model with respect to the substance under
investigation the results and the conclusions thereoff should be treated
Henry´s Law constant:
The value obtained from the SRC database is
based on a QSAR prediction performed. The QSAR prediction was made using
EPISuiteTM HenryWin (model) and revealed a value of 1.39E-11 Pa-m³/mol
References: Blume, H. P., & Ahlsdorf, B.
(1993). Prediction of pesticide behavior in soil by means of simple
field tests.Ecotoxicology and environmental safety,26(3),
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