Registration Dossier
Registration Dossier
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EC number: 280-479-2 | CAS number: 83547-95-9
Endpoint summary
Administrative data
Description of key information
The LC50 of water emulsions of TK 12 184 in solvent carriers was calculated to be 8.25 mg/L (95% confidence limits: 6.91 - 9.86 mg/11 mg/L) in rainbow trout, and 4.05 mg/L (95% confidence limits: 3.21 - 5.11 mg/L) in Zebrafish. The IC50 (24 h) for water suspensions of TK 12 184 in Daphna magna, corrected with the Bichromate-value, was calculated as 12.54 mg/L. Water emulsions / suspensions were prepared due to the low water solubility of the test substance.
In an algal growth inhibition study of TK 12 184, the EbC50 (0 - 72 h) was 3.1 mg/L (95% confidence limits: 2.2 - 3.9 mg/L). The NOEbC was 0.1 mg/L. Values were based on actual end of exposure concentrations.
Additional information
The US EPA WSKOWWIN V1.42 model estimates the water solubility of TGEPO (CAS No. 83547-95-9) to be 1.798e-007 mg/L at 25 deg C.
The US EPA ECOSAR v1.11 model predicts no effects at saturated concentrations in water for TGEPO (CAS No. 83547-95-9). The estimated logKow for this substance is greater than the class specific cut-offs for aquatic toxicity, and the predicted effect levels exceed the estimated water solubility of this substance by more than 10x.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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