Registration Dossier
Registration Dossier
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EC number: 280-479-2 | CAS number: 83547-95-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No specific studies of TGEPO basic toxicokinetics or dermal absorption are available. Relevant physical/chemical properties include:
- very low water solubility (estimated by the US EPA WSKOWWIN V1.42 model to be 1.798e-007 mg/L at 25 deg C).
- high LogKow (estimated by the US EPA KOWWIN v1.68 model to be 10.04).
- high molecular weight (656.945)
The US EPA BCFBAF v3.01 model estimates the BCF and BAF of TGEPO (CAS No. 83547-95-9) to be 109 and 0.898 L/kg, respectively, indicating that the substance does not bioaccumulate.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
TGEPO is expected to have limited absorption due to its high Kow, very low water solubility and high molecular weight, as discussed in ECHA guidance (Chapter R.7c, 2017). Based on ECHA guidance for substances with molecular weight > 500 and logKow < -1 or > 4, a default dermal absorption rate of 10% is assumed for TGEPO.
The absorption efficiencies used in the assessment are:
Dermal - 10%
Oral - 50%
Inhalation - 50%
As a phosphate ester, TGEPO is expected to be susceptible to hydrolysis.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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