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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Remarks:
Solubility in n-octanol
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From July 2017 to September 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: OECD Guideline No. 105 (1995)
Deviations:
yes
Qualifier:
according to guideline
Guideline:
other: Commission Regulation (EC) No. 440/2008 EC A6 method (2008)
Deviations:
no
GLP compliance:
no
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Batch No.of test material: 24/02/2016
- Expiration date of the lot/batch: July 2021
- Purity test date: July 2016

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: In darkness at room temperature
Key result
Medium:
n-octanol
Solubility:
302 g/L
Temp.:
20 °C
Remarks on result:
other: Expressed in Solvent N1
Medium:
n-octanol
Solubility:
229 g/L
Temp.:
20 °C
Remarks on result:
other: Expressed in 1-chloro-2-(difluoromethoxy)- 1,1,2,3,3,3-hexafluoro-propane
Test substance stable:
yes

Table 1:

Preliminary test

 

 

Weight

of test item

(g)

Volume

of water

(mL)

Solubility*

(g/L)

 

1.95092

1

No

/

5

No

/

10

No

/

20

Yes

100 - 200

 

Table 2 : 

Main test

 

 

Concentration (mg/L)

Dilution

factor

Final

concentration

1-chloro-2-

(difluoromethoxy)-

1,1,2,3,3,3,-

hexafluoropropane

 (g/L)

Final

conconcentration

in

SOLVENT

N1

(g/L)

After 24h

229.3

1000

22.3

303.2

241.1

1000

241.1

319.0

After 48h

231.5

1000

231.5

306.2

221.0

1000

221.0

292.3

After 72h

220.0

1000

220.0

290.9

229.3

1000

229.3

303.2

Mean

 

229

302

SD

8.6

11

RSD (%)

3.78

10.7
Conclusions:
The solubility in n-octanol of Reaction mass of 1-chloro-2-(difluoromethoxy)-1,1,2,3,3,3-hexafluoro-propane and 2-difluoromethoxy-1,1,1,2,3,3,3-eptafluoro-propane performed at 20 0 °C ± 2.0 °C was 229 g/L.
The solubility in n-octanol of the test item expressed as SOLVENT N1 at 20 0 °C ± 2.0 °C was 302 g/L.
Executive summary:

The solubility in n-octanol of the test item was determined with Shake flask method according to recognized guidelines (OECD Guideline 105 and EU Method A.6) . No deviation from the guideline was observed during the study.

The solubility in n-octanol of reaction mass of 1-chloro-2-(difluoromethoxy)-1,1,2,3,3,3-hexafluoro-propane and 2-difluoromethoxy-1,1,1,2,3,3,3-eptafluoro-propane performed at 20 0 °C ± 2.0 °C was 229 g/L.

The solubility in n-octanol of the test item expressed as SOLVENT N1 at 20 0 °C ± 2.0 °C was 302 g/L.

Description of key information

One reliable key study (Klimisch 1) is available.

The solubility in n-octanol of the test item was determined with Shake flask method according to recognized guidelines (OECD Guideline 105 and EU Method A.6). No deviations from the guideline were observed during the study.

The solubility in n-octanol of reaction mass of 1-chloro-2-(difluoromethoxy)-1,1,2,3,3,3-hexafluoro-propane and 2-difluoromethoxy-1,1,1,2,3,3,3-eptafluoro-propane performed at 20 0 °C ± 2.0 °C was 229 g/L.

The solubility in n-octanol of the test item expressed as SOLVENT N1 at 20 0 °C ± 2.0 °C was 302 g/L.

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
229 g/L

Additional information