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EC number: 276-339-5 | CAS number: 72102-40-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Trimethyl-3-[(1-oxo-10-undecenyl)amino]propylammonium methyl sulphate
- EC Number:
- 304-990-8
- EC Name:
- Trimethyl-3-[(1-oxo-10-undecenyl)amino]propylammonium methyl sulphate
- Cas Number:
- 94313-91-4
- Molecular formula:
- C17H35N2O.CH3O4S
- IUPAC Name:
- methyl sulfate;trimethyl-[3-(undec-10-enoylamino)propyl]azanium
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- water
- Reference substance name:
- Ethanol
- EC Number:
- 200-578-6
- EC Name:
- Ethanol
- Cas Number:
- 64-17-5
- Molecular formula:
- C2H6O
- IUPAC Name:
- Ethyl alcohol
- Test material form:
- solid
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test substance
- Age at study initiation: no data
- Weight at study initiation: m: 125 - 135g; f: 110 - 125g
- Fasting period before study: over night
- Housing: single caging, cage type: Macrolon type IlI./max. 5
- Diet: ad libitum; rat diet (R 4 Alleindiät für Ratten), Ssniff Spezialdiäten GmbH, 4770 Soest/Westfalen
- Water: ad libitum
- Acclimation period: 11 d
Environment conditions
- Temperature (°C): 20 - 23
- Humidity (%): 40 - 70
- Air changes (per hr): 10 per h
- Photoperiod (h dark / h light): 12 h daily
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Vehicle
- Concentration in vehicle: 500 mg/mL
- Amount of vehicle (if gavage): 10 mL/kg bw
The test substance was weighed out in a glass, then was filled with Aqua destillata up to the desired volume, was shaken well and afterwards labeled. The formulated test substance was a clear solution. - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- The group of 5 female and 5 male rats were were given a single oral dose 5000 mg/kg of the test substance by gavage.
- Duration of observation period following administration: 14 d
- Body weights were recorded before treatment (Day 1), at the treatment day (Day 0), and on Days 7 and 14 after treatment
- Clinical observation: Animals were observed 1/4 h, 1/2 h, 1 h, 2 h, 4 h after dosing and thereafter once daily up to day 14.
- Necropsy of the survivors performed: yes - Statistics:
- As none of the test animals died a calculation of the LD50 was not possible.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: mortality 0/10
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 350 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: mortality 0/10
- Mortality:
- There were no mortalities.
- Clinical signs:
- other: Except of ruffled fur on the day of treatment, the animals were free of clinical-/toxicological symptoms during the entire observation period of 14 d.
- Gross pathology:
- Necropsies were performed on all animals at the end of the 14 d observation period. In one animal a slight thickening of the stomach mucosa could be observed. Necropsies of all other animals showed no test compound related macroscopic findings in the cranial, thoracic and abdominal cavity.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified based on EU CLP criteria
- Conclusions:
- Under the study conditions, the oral LD50 value of the test substance was determined to be >5000 mg/kg bw (i.e., equivalent to > 2350 mg a.i./kg bw).
- Executive summary:
A study was conducted to determine the acute oral toxicity of the test substance, 'C11-unsatd. AAP TMA-MS (active: 47%)' according to a method similar to OECD Guideline 401. In the study, 5 male and 5 female Sprague-Dawley rats were given a single dose of the test substance at a dose of 5000 mg/kg bw (limit test). The test substance was formulated in water and applied in a volume of 10 mL/kg bw. Animals were subsequently observed for 14 consecutive days. There were no deaths following a single oral dose of the test substance. Except of ruffled fur on the day of treatment, the animals were free of clinical/ toxicological signs during the entire observation period of 14 d. Necropsies were performed on all animals at the end of the 14 d observation period. In one animal a slight thickening of the stomach mucosa could be observed. Necropsies of all other animals showed no test compound related macroscopic findings in the cranial, thoracic and abdominal cavity. Under the study conditions, the oral LD50 value of the test substance was determined to be >5000 mg/kg bw (i.e., equivalent to > 2350 mg a.i./kg bw) (Meisel, 1983).
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