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EC number: 201-818-2 | CAS number: 88-30-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-03-16 to 1994-04-04
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 1987-02-24
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- 1992-07-31
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- α,α,α-trifluoro-4-nitro-m-cresol
- EC Number:
- 201-818-2
- EC Name:
- α,α,α-trifluoro-4-nitro-m-cresol
- Cas Number:
- 88-30-2
- Molecular formula:
- C7H4F3NO3
- IUPAC Name:
- α,α,α-trifluoro-4-nitro-m-cresol
- Reference substance name:
- 5-chloro-α,α,α-trifluoro-2-nitrotoluene
- EC Number:
- 204-280-7
- EC Name:
- 5-chloro-α,α,α-trifluoro-2-nitrotoluene
- Cas Number:
- 118-83-2
- Molecular formula:
- C7H3ClF3NO2
- IUPAC Name:
- 4-Chloro-1-nitro-2-(trifluoromethyl)benzene
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Dihydrogen oxide
- Reference substance name:
- 3-Carboxy-4-nitrophenol
- Cas Number:
- 610-37-7
- Molecular formula:
- C7H5NO5
- IUPAC Name:
- 3-Carboxy-4-nitrophenol
- Test material form:
- liquid
Constituent 1
impurity 1
impurity 2
impurity 3
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Batch No. of test material: C02910506
- Expiration date of the batch: 1995-02
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature, in the dark, under fume cupboard
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- WISKf (SPD71)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund SPF breeding colony
- Age at study initiation: ♂ ~7 weeks, ♀ ~9 weeks
- Weight at study initiation: ♂ ~191 g, ♀ ~213 g
- Diet: ad libitum, Altromin 1324 rat diet
- Water: ad libitum, tap water
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 50 ± 20
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal skin
- coverage: ~30 cm²
- Type of wrap if used: Fixomull and Elastoplast
REMOVAL OF TEST SUBSTANCE
- Washing: yes, with warm water
- Time after start of exposure: 24 h - Duration of exposure:
- 24 h
- Doses:
- 315, 400, and 500 mg/kg bw
- No. of animals per sex per dose:
- 5 ♀, 5 ♂ (only at 400 mg/kg bw)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: twice every day for clinical symptoms and mortality (on weekends and on national holidays only once), weighing on day 8 and day 15.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights - Statistics:
- The LD50 was established in female animals on the basis of the lethality rates by probit analysis (method of Fieller and Sidak, programs supplied by Pharma research and Development Informatics, HOECHST AG).
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 265.5 mg/kg bw
- Based on:
- act. ingr.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 409.1 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: based on the 64.9 % solution of the test substance
- Mortality:
- ♀: In the 315 mg/kg bw dose group 1 out of 5 animals died. In the 400 mg/kg bw dose group 2 out of 5 animals died. In the 500 mg/kg bw dose group 4 out of 5 animals died.
♂: In the 400 mg/kg bw dose group 2 out of 5 animals died. - Clinical signs:
- other: Decreased spontaneous activity, silted gait, irregular respiration, and tonoclonic convulsion. Additionally in the 400 and 500 mg/kg bw dose group squatting posture and prone position. Two days after application all clinical signs were reversible.
- Gross pathology:
- Animals died during the observation period showed light discolorations and demarcation of the liver. Surviving animals showed no macroscopically visible changes.
Any other information on results incl. tables
The skin of the animals showed erythrema, yellow discoloratios and indurations. Furthermore, scabbed skin, coarse or fine scales, desquamations of coarse or fine scales and parchment-like skin surface. Scar formation occurred in all dose groups at the treated skin areas.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The LD50 of the test substance in rat was 265.4 mg/kg bw, based on the 64.9 % solution of the test substance.
- Executive summary:
In an acute dermal toxicity study according to OECD guideline 402, groups of 7 - 9 week old Wistar (WISKf (SPD71) rats (5♀/dose, 5 ♂ at 400 mg/kg bw) were dermally exposed to the test substance for 24 hours to 10 % (6 x 5 cm) skin surface at doses of 315, 400, and 500 mg/kg bw (Hoechst AG, 1994). Animals then were observed for 14 days. Following clinical signs were observed: decreased spontaneous activity, silted gait, irregular respiration, and tonoclonic convulsion. Additionally in the 400 and 500 mg/kg bw dose group, squatting posture and prone position. Two days after application all clinical signs were reversible. No abnormalities were observed at necroscopy. A dermal LD50 of 409.1 mg/kg bw was determined. A LD50 of 265.5 mg/kg bw of the active ingredient based on the 64.9 % solution of the test substance was determined.
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