Registration Dossier
Registration Dossier
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EC number: 915-672-9 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Guideline study according to GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- 3 times a week
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- · Source, supplier, any pretreatment, breeding method:
Supplied by NIES
· Age at study initiation: < 24 h old
· Pretreatment: The group of parents, which showed less than 5% mortality for14 days
prior to test, was used. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 21 d
- Post exposure observation period:
- NA
- Hardness:
- 220-245 mg/L as CaCO3
- Test temperature:
- 19.8-20.2
- pH:
- 7.2-8.4
- Nominal and measured concentrations:
- Nominal: 100 mg/L
Measured: 92-97 mg/L - Key result
- Duration:
- 21
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Key result
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Results with reference substance (positive control):
- NA
- Validity criteria fulfilled:
- yes
- Conclusions:
- After 21 days an EC50 of 100 mg/L and a NOEC of ≥ 100 mg/L was determined.
- Executive summary:
A chronic toxicity study was consucted according to the OECD TG no. 211.
The study followed GLP and was conducted as a limit test (100 mg/L) and semi static with renewal of the test solutions 3 times a week.
After 21 days an EC50 of 100 mg/L and a NOEC of ≥ 100 mg/L was determined.
Reference
Description of key information
A chronic toxicity study was consucted according to the OECD TG no. 211.
The study followed GLP and was conducted as a limit test (100 mg/L) and semi static with renewal of the test solutions 3 times a week.
After 21 days an EC50 of 100 mg/L and a NOEC of ≥ 100 mg/L was determined.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
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