Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-451-9 | CAS number: 2155-60-4
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 June 2015 - 16 July 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- (2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- (2004)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Version / remarks:
- (1996)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.8
- Remarks on result:
- other: Non-buffered mobile phase
- Type:
- Pow
- Partition coefficient:
- 6 600
- Remarks on result:
- other: Non-buffered mobile phase
- Details on results:
- In the HPLC chromatogram of the test substance solution, one test substance peak was observed (see attached document).
- Conclusions:
- Using the HPLC method with a non-buffered mobile phase and detection at 210 nm, the log Pow of Dibutyl itaconate has been determined as 3.8. The study is performed in accordance with EC A.8, OECD 117 and EPA OPPTS 830.7570 guidelines and in compliance with GLP.
Reference
Table: Results HPLC method (partition coefficient n-octanol-water)
Substance |
tr,1 |
tr,2 |
mean tr |
log Pow |
Pow |
Area |
|
|
|
|
|
|
|
Formamide (t0) |
0.560 |
0.562 |
0.561 |
|
|
|
|
|
|
|
|
|
|
Nitrobenzene |
0.891 |
0.890 |
|
1.9 |
|
|
Bromobenzene |
1.468 |
1.467 |
|
3.0 |
|
|
1,4-Dichlorobenzene |
1.823 |
1.822 |
|
3.4 |
|
|
Biphenyl |
2.433 |
2.432 |
|
4.0 |
|
|
1,2,4-Trichlorobenzene |
2.812 |
2.810 |
|
4.2 |
|
|
Dibenzyl |
4.014 |
4.012 |
|
4.8 |
|
|
|
|
|
|
|
|
|
Test substance |
2.214 |
2.211 |
2.213 |
3.8 |
6.6E03 |
100 |
|
|
|
|
|
|
|
Description of key information
Using the HPLC method with a non-buffered mobile phase and detection at 210 nm, the log Pow of Dibutyl itaconate has been determined as 3.8. The study is performed in accordance with EC A.8, OECD 117 and EPA OPPTS 830.7570 guidelines and in compliance with GLP.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.8
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
