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EC number: 271-807-5 | CAS number: 68608-88-8 This substance is identified by SDA Substance Name: C11-C13 branched alkyl benzene sulfonic acid and SDA Reporting Number: 25-096-00.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented journal article.
- Justification for type of information:
- Read Across from peer reviewed acute toxicity study reported in scientific literature conducted on branched alkyl benzene sulfonate with nominal chain length of 12 carbon atoms (range C10 - C14) and Linear Alkyl Benzene sulfonate with a nominal chain length of 12 carbon atoms (range C9 - C15).
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented journal article.
- Justification for type of information:
- Read Across from peer reviewed acute toxicity study reported in scientific literature conducted on branched alkyl benzene sulfonate with nominal chain length of 12 carbon atoms (range C10 - C14) and Linear Alkyl Benzene sulfonate with a nominal chain length of 12 carbon atoms (range C9 - C15).
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: Hagan, EC (1959). Acute toxicity. In: Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics. pp. 17-25. Assoc. of Food and Drug Officials of the US, Bureau of Food and Drugs, Texas State Dept. of Health, Austin, Texas.
- GLP compliance:
- no
- Remarks:
- Study performed in 1965 prior to implementation of GLP.
- Limit test:
- no
- Species:
- rat
- Strain:
- other: FDRL
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adult
- Fasting period before study: overnight - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10% dispersion in water, LAS was also given in a 40% dispersion
- Purity: distilled water - Doses:
- graded doses
LAS: 0.6, 1.58 g/kg - No. of animals per sex per dose:
- 3 rats of each sex per dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations for behaviour, appearance and survival were made daily; weighings were performed on days 0, 7, and 14
- Necropsy of survivors performed: yes - Statistics:
- LD50 calculated by the method of Miller, LC, and Tainter, ML. (1994). Estimation of the ED50 and its error by means of logarithmic-probit graph paper. Proc. Soc. Exptl. Biol. Med. 57, 261-264.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 0.52 other: g/kg
- Based on:
- act. ingr.
- 95% CL:
- 0.424 - 0.614
- Remarks on result:
- other: ABS
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 0.65 other: g/kg
- Based on:
- act. ingr.
- 95% CL:
- 0.587 - 0.713
- Remarks on result:
- other: LAS
- Mortality:
- No effects.
- Clinical signs:
- other: At the high LAS dose, a high incidence of diarrhea was noted. Animals that died during the study showed weakness and reduced activity prior to death.
- Gross pathology:
- No effects.
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The acute oral LD50 for ABS in rats is 520 mg/kg bw. This places ABS in toxicity category 4.
- Executive summary:
Groups of 3 male and 3 female rats were administered various doses of branched alkyl benzene sulfonate (ABS) with nominal chain length of 12 carbon atoms (range C10 - C14) and Linear Alkyl Benzene sulfonate (LAS) with a nominal chain length of 12 carbon atoms (range C9 - C15). The animals were oberseved for 14 days for survival, behaviour, and appearance. In addition, body weights were taken on days 0, 7, and 14. The LD50 for ABS was 520 mg/kg, and the LD50 for LAS was 650 mg/kg. The LD50s for LAS and ABS were not statistically different. This demonstrates that LAS is a suitable analog for ABS regarding toxicity.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicologic Studies with Branched and Linear Alkyl Benzene Sulfonates in Rats
- Author:
- Oser, BL, and Morgareidge, K
- Year:
- 1 965
- Bibliographic source:
- Toxicology and Applied Pharmacology 7, 819-25
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Hagan, EC (1959). Acute toxicity. In: Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics. pp. 17-25. Assoc. of Food and Drug Officials of the US, Bureau of Food and Drugs, Texas State Dept. of Health, Austin, Texas.
- GLP compliance:
- no
- Remarks:
- Study performed in 1965 prior to implementation of GLP.
- Limit test:
- no
Test material
- Reference substance name:
- LAS
- IUPAC Name:
- LAS
- Reference substance name:
- ABS
- IUPAC Name:
- ABS
- Details on test material:
- This study compared the toxicity of branched alkyl benzene sulfonates (ABS) to that of linear alkyl benzene sulfonates (LAS).
ABS:
- Physical state: off-white powder
- Impurities (identity and concentrations): petroleum ether-soluble 0.9%, sodium sulfate 10.5%, water 2.2%
- Composition of test material, percentage of components: 87.1% active ABS, average molecular weight 347, average chain length 12
LAS:
- Physical state: yellow viscous liquid
- Impurities (identity and concentrations): free alkali 0.05%, sodium sulfate 8.8%, water 50.9%
- Composition of test material, percentage of components: 39.5% active ABS, average molecular weight 346, average chain length 12
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: FDRL
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adult
- Fasting period before study: overnight
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10% dispersion in water, LAS was also given in a 40% dispersion
- Purity: distilled water - Doses:
- graded doses
LAS: 0.6, 1.58 g/kg - No. of animals per sex per dose:
- 3 rats of each sex per dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations for behaviour, appearance and survival were made daily; weighings were performed on days 0, 7, and 14
- Necropsy of survivors performed: yes - Statistics:
- LD50 calculated by the method of Miller, LC, and Tainter, ML. (1994). Estimation of the ED50 and its error by means of logarithmic-probit graph paper. Proc. Soc. Exptl. Biol. Med. 57, 261-264.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 0.52 other: g/kg
- Based on:
- act. ingr.
- 95% CL:
- 0.424 - 0.614
- Remarks on result:
- other: ABS
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 0.65 other: g/kg
- Based on:
- act. ingr.
- 95% CL:
- 0.587 - 0.713
- Remarks on result:
- other: LAS
- Mortality:
- No effects.
- Clinical signs:
- other: At the high LAS dose, a high incidence of diarrhea was noted. Animals that died during the study showed weakness and reduced activity prior to death.
- Gross pathology:
- No effects.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The acute oral LD50 for ABS in rats is 520 mg/kg bw. This places ABS in toxicity category 4.
- Executive summary:
Groups of 3 male and 3 female rats were administered various doses of branched alkyl benzene sulfonate (ABS) with nominal chain length of 12 carbon atoms (range C10 - C14) and Linear Alkyl Benzene sulfonate (LAS) with a nominal chain length of 12 carbon atoms (range C9 - C15). The animals were oberseved for 14 days for survival, behaviour, and appearance. In addition, body weights were taken on days 0, 7, and 14. The LD50 for ABS was 520 mg/kg, and the LD50 for LAS was 650 mg/kg. The LD50s for LAS and ABS were not statistically different. This demonstrates that LAS is a suitable analog for ABS regarding toxicity.
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