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EC number: 274-393-4
CAS number: 70209-96-0
Evaluation of the Skin Reactions
A study was performed to determine the
skin irritation potential of test item on Russian breed rabbits
according to "Appraisal of the Safety of Chemicals in Foods, Drugs and
Cosmetics" (1959) of the US Association of Food and Drug Officials
3 males and 3 females rabbits were shaved
on the whole back and flanks two days before treatment with an electric
clipper. The shaven skin on the left side was slightly scarified
immediately before treatment. The test item was applied to each side in
quantities of 0.5 g; before application a 50 % polyethylene glycol
trituration (PEG 400) was made.
The primary irritation index as the
measure of the acute skin irritation provoked by the substance is
defined as the average of all the ratings found after 24 and 72 hours on
the intact and slightly scarified skin.
The primary irritation index, as the
measure of the acute irritation to the skin of rabbits, was found to be
0; therefore test item resulted to be as non-irritant to the skin of
Discussion and conclusion
The scoring system criteria used to record
the severity of the skin reactions followed in the current test are the
same as those reported into the OECD guideline, therefore it is possible
to re-evaluate the results in accordance with the CLP Regulation (EC) No
None of the animals showed any observable
response to treatment throughout the 72 hours observation period, in
both the cases of intact and scarified skin. Therefore, it can be
concluded that the test item does not meet the criteria to be classified
as irritating, according to the CLP Regulation (EC) No 1272/2008.
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