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EC number: 218-080-2
CAS number: 2050-08-0
A study was performed to determine the acute oral median lethal dose
(LD50) of the test material, administered as a solution in arachis oil
B.P in the Sprague-Sawley strain rat. The method used followed that
described in the OECD Guideline for Testing of Chemicals (1981) No, 401
"Acute Oral Toxicity".
Following a range finding study, a group of ten fasted animals (five
males and five females) was given a single oral dose of test material
preparation at a dose level of 2000mg/kg bw.
Five animals (three males and two females) were found dead one to three
days after treatment. Signs of toxicity noted were hunched posture,
lethargy and pilo-erection. Additional or isolated signs of toxicity
noted were ptosis, red/brown staining around the snout and eyes, ataxia,
dehydration, tiptoe gait and decreased respiratory rate. Surviving
animals appeared normal four days after treatment.
Incidents of reduced gain in bodyweight and body loss were noted during
the study period.
Abnormalities noted at necropsy of animals that died during the study
were haemorrhagic or abnormally red lungs, dark or pale liver, pale
spleen, haemorrhage of the glandular gastric epithelium, sloughing of
the non-glandular gastric epithelium and haemorrhage of the small
Abnormalities noted at necropsy of animals that were killed at the end
of the study included included pale liver, adhesion of the stomach to
the liver and multiple white foci approximaely 2mm x 2mm over 75% of the
non-glandular epithelium of the stomach.
No abnormalities were noted at necropsy of the three remaining animals
that were killed at the end of the study.
The acute oral median lethal dose (LD50) of the test material, HR
90/660541, to the Sprague Dawley strain rat was considered to be
approximately 2000mg/kg bw.
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