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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin corrosion: in vitro / ex vivo
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:
At physiological pH, all lithium borates dissociate and release boric acid and lithium ions as a result of relevant transformation pathways. It will the boric acid component of the substances which will drive the mammalian toxicity endpoints. Variations in the structure (trigonal vs tetrahedral) between the substances are not expected to lead to any changes in corrosivity. In order to minimise animal testing, only one substance in the category was tested, dilithium tetraborate. For all other substances in the category, read-across is proposed.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
lithium(1+) tetrahydroxyboranuide
EC Number:
818-953-3
Cas Number:
12006-96-1
Molecular formula:
LiB(OH)4
IUPAC Name:
lithium(1+) tetrahydroxyboranuide

Results and discussion

In vitro

Resultsopen allclose all
Irritation / corrosion parameter:
% tissue viability
Run / experiment:
3 minute
Value:
93
Vehicle controls validity:
not applicable
Negative controls validity:
valid
Positive controls validity:
valid
Remarks on result:
other: not corrosive
Irritation / corrosion parameter:
% tissue viability
Run / experiment:
1 hour
Value:
99
Vehicle controls validity:
not applicable
Negative controls validity:
valid
Positive controls validity:
valid
Remarks on result:
other: not corrosive

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
An OECD 431 study was conducted on dilithium tetraborate and found to be non-corrosive. Lithium tetrahydroxyborate is also expected to be non-corrosive.
Executive summary:

An OECD 431 study was conducted on dilithium tetraborate and found to be non-corrosive. Variations in the structure (trigonal vs tetrahedral) between the substances are not expected to lead to any changes in corrosivity as at physiological pH, all the substances dissociate to provide the same common compounds. All substances in the category do not meet CLP criteria for classification as skin irritants.

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