Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 701-475-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- A literature review of available data which is considered relevant to dilithium tetraborate was conducted to ascertain the potential for skin sensitisation effects.
At physiological pH, the substances dissociate and release boric acid and lithium ions as a result of relevant transformation pathways. The literature review looked at a range of borate substances including boric acid, disodium tetraborate anhydrous, disodium tetraborate pentahydrate and disodium tetraborate decahydrate which reported no signs of skin sensitisation. Data collected in the weight of evidence report also noted that it is unlikely that the lithium cation would cause sensitisation by skin contact. As lithium tetrahydroxyborate will dissociate to the same common compounds, then the weight of evidence report can also be used to cover the sensitisation endpoint for the REACH registration of the UVCB-Reaction products of boric acid and lithium hydroxide.
Data source
Materials and methods
Test material
- Reference substance name:
- Dilithium tetraborate
- EC Number:
- 234-514-3
- EC Name:
- Dilithium tetraborate
- Cas Number:
- 12007-60-2
- Molecular formula:
- B4Li2O7
- IUPAC Name:
- dilithium tetraborate
- Test material form:
- solid: bulk
Constituent 1
Results and discussion
In vivo (non-LLNA)
Results
- Key result
- Remarks on result:
- other: Weight of evidence approach
- Remarks:
- This is a weight of evidence which is based on different types of data which are considered relevant to the assessment of the likelihood of skin sensitising effects.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the available in vivo test data for analogous substances which indicate an absence of skin sensitising effect, an absence of evidence from widespread consumer and occupational use of inorganic borates and very low dermal penetration, it can be concluded that all lithium borates are unlikely to cause sensitisation by skin contact.
- Executive summary:
A literature review of available data which is considered relevant to dilithium tetraborate was conducted to ascertain the potential for skin sensitisation effects. At physiological pH, the lithium borates dissociate and release boric acid and lithium ions as a result of relevant transformation pathways. The literature review looked at a range of borate substances including boric acid, disodium tetraborate anhydrous, disodium tetraborate pentahydrate and disodium tetraborate decahydrate which reported no signs of skin sensitisation. Data collected in the weight of evidence report also noted that it is unlikely that the lithium cation would cause sensitisation by skin contact. As the UVCB-Reaction products of boric acid and lithium hydroxide will dissociate to the same common compounds as dilithium tetraborate, then the weight of evidence report can also be used to cover the sensitisation endpoint for the REACH registration of the UVCB-Reaction products of boric acid and lithium hydroxide. Classification as a skin sensitiser is therefore not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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