2-Propenenitrile, reaction products with 2,2,4(or 2,4,4)-trimethyl-1,6-hexanediamine

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2018-05-07 to 2018-05-29

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

refer to Principles of method if other than guideline

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

yes

Remarks:

refer to Principles of method if other than guideline

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Deviations:

yes

Remarks:

refer to Principles of method if other than guideline

Principles of method if other than guideline:

A miscibility test was carried out to evaluate the solubility of the test item in water. Although, this procedure deviates from the guideline, it is considered scientifically valid.

GLP compliance:

yes (incl. QA statement)

Type of method:

other: miscibility test with visual inspection

Key result

Temp.:

20 °C

pH:

>= 11.7 - <= 13.2

Remarks on result:

completely miscible

The miscibility of the test item with ultrapure water was investigated at three different ratios. Single-phase clear solution was observed at all tested ratios, thus, the test item is considered to be miscible with water.

 

Test item : water ratio	Volume of Test Item	Volume of Water	Observation	pH
1 : 9	1 mL	9 mL	Single-phase clear solution	11.7
9 : 1	9 mL	1 mL	Single-phase clear solution	13.2
1 : 1	5 mL	5 mL	Single-phase clear solution	12.6

 

Conclusions:

The test item is completely miscible in water at different ratios.

Executive summary:

The water solubility was determined according to OECD 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840. In a preliminary test no saturated solution of the test item could be prepared, therefore, the standard methods for determination of the water solubility are technically not feasible. Therefore, the water solubility of the test item was determined using the miscibility test with visual detection. The test item was mixed with ultrapure water in ratios 1 :1, 1 : 9 and 9 : 1. After sonication and vigorous shaking the solubility was visually detected. The pH of each sample was recorded. The test substance was determined to be completely miscible in water at ambient temperature.

Description of key information

The test item is completely miscible in water at ambient temperature. For further risk assessment a maximum default value of 100000 mg/L was used.

Key value for chemical safety assessment

Water solubility:

100 000 mg/L

at the temperature of:

20 °C

Additional information

The water solubility was determined according to OECD 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840. In a preliminary test no saturated solution of the test item could be prepared, therefore, the standard methods for determination of the water solubility are technically not feasible. Therefore, the water solubility of the test item was determined using the miscibility test with visual detection. The test item was mixed with ultrapure water in ratios 1 :1, 1 : 9 and 9 : 1. After sonication and vigorous shaking the solubility was visually detected. The pH of each sample was recorded. The test substance was determined to be completely miscible in water at ambient temperature.