Registration Dossier
Registration Dossier
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EC number: 208-594-5 | CAS number: 534-22-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Genetic toxicity
5 in vitro studies are available, of which two were disregarded due to significant methodological deficiencies. The remaining three studies are Ames studies. In all 3 Ames studies, 2-Methylfuran was tested negative with and without metabolic activation.
There is also one in vivo study available, which however was scored to be a K4 study. In this study, 2 -methylfuran did not cause any genotoxic hazards to the mammalian test system.
Taking all available in vitro data together in a weight of evidence approach, results in an overall negative outcome for genotoxicity. This is further supported by the in vivo study. In conclusion, the substance should not to be considered as genotoxic/mutagenic according to Regulation EC No 1272/2008, section 3.5.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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