Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
30th March, 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
effusion method: isothermal thermogravimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of 4,4'-methylenediphenol and 2,2'-methylenediphenol and o-[(4-hydroxyphenyl)methyl]phenol
EC Number:
908-912-9
Cas Number:
1333-16-0
Molecular formula:
C39H36O6
IUPAC Name:
Reaction mass of 4,4'-methylenediphenol and 2,2'-methylenediphenol and o-[(4-hydroxyphenyl)methyl]phenol
Test material form:
solid
Specific details on test material used for the study:
Manufacturer: Kukdo Chemical
Appearance: Solid
Chemical name: Bisphenol F
CAS: 1333-16-0
Purity: 98%

Results and discussion

Vapour pressureopen allclose all
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0 Pa
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0 mm Hg
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0 mm Hg

Any other information on results incl. tables

The results of the isothermal TGA analysis for the test substance and vapor pressure at 20°C and 25 °C are given in the tables below. The plot of log PT of the test substance as a function of the reciprocal temperatures is shown in figure 2. The equation of the curve is log PT = 6143.6 x 1/T + 16.833 (r² = 0.9999, n = 7

Table 1 - Results of Isothermal TGA Analysis: 

Temperature (°C)  weight loss (g)  log Vt  log Pt  Pt
 130 6.20x10E-5  -2.96  1.63 43.12 
 130  5.27 x 10 -5  -3.03  1.55 35.15 
 140  1.17 x 10 -4  -2.69  1.98 95.91 
 140  1.05 x 10 -4  -2.73  1.92 83.86 
 150  2.19 x 10 -4  -2.42  2.32 209.7 
 150  2.06 x 10 -4  -2.44  2.29 194.31 
 160  4.01 x 10 -4  -2.15  2.65 448.2 
 160  3.88 x 10 -4  -2.17  2.63 430.87 
 170  7.36 x 10 -4  -1.89  2.98 961.05 
 170  7.06 x 10 -4  -1.91  2.96 911.19 
 180  1.31 x 10 -3  -1.64  3.30 1982.81 
 180  1.24 x 10 -3  -1.66  3.27 1841.53 
 190  2.17 x 10 -3  -1.42  3.57 3740.31 
 190  2.03 x 10 -3  -1.45  3.54

3429.98 

Table 2: Vapour pressure of the test substance:

 Temperature (°C)  Log PT  PT (Pa)  PT (mmHg)
 20 -4.14  7.3x10 -5  5.5x10 -7 
 25 -3.78  1.7x10 -4  1.2x10 -6 
 50 -2.19  6.5x10 -3  4.9x10 -5 

Applicant's summary and conclusion

Conclusions:
The Isothermal TGA effusion method was used for the determination of vapor pressure of Bisphenol F. Vapor pressure of the test substance at 20 °C and 25°C was 5.5 x 10E-7 mmHg and 1.2 x 10E-6 mmHg.

Test item: Bisohenol F
Vapor pressure at 20°C - 7.3 x 10E-5 (5.5 x 10E-7 Pa)
Vapor pressure at 25 °C - 1.7x10E-4 (1.2 x 10E-6 Pa)
Executive summary:

Microbial degradation of Bisphenol-F (Reaction mass of 2,2’-methylenediphenol and 4,4’-methylenediphenol and o-[(4-hydroxyphenyl)methyl]phenol) was performed for 28 days following Testing Guidelines for Studies of Chemicals, Section 4.3, “Biodegradation Study (Ready Biodegradability) : Modified MITI(I)” (Notification No. 2017-4, issued by the National Institute of Environmental Research, Korea on March 14, 2017) and OECD Guidelines for Testing of Chemicals, 301C, “Ready Biodegradability-MITI(I) (Adopted : 17th July 1992)”.

The results of microbial degradation of Bisphenol-F(Reaction mass of 2,2’-methylenediphenol and 4,4’-methylenediphenol and o-[(4-hydroxyphenyl)methyl]phenol) were as follows;

The percentage biodegradations of the reference compound, Sodium benzoate, observed by BOD measurement were 86.2 % after 7 days and 85.7 % after 14 days. The test was valid that the results were within the acceptable range specified by the OECD guideline.

2) The percentage biodegradations of the test substance, Bisphenol-F(Reaction mass of 2,2’-methylenediphenol and 4,4’-methylenediphenol and o-[(4-hydroxyphenyl)methyl]phenol), observed by BOD measurement were calculated with a range of 31.8 ~ 33.9 % and the average percentage biodegradation was calculated to be 32.9 % after 28 days. Therefore, these results indicate that the test substance is not biodegradable in aqueous condition. The percentage biodegradation based on the residual amount of test substance by HPLC analysis was calculated to be 45.6 %.

As a result, the test substance could not be concluded as readily degradable by microorganisms in the aquatic environment because the percentage biodegradation of the test substance by BOD measurement was less than pass level for ready biodegradability (60%) specified by the OECD guideline.