2-[(2-hydroxyphenyl)methyl]phenol; 2-[(4-hydroxyphenyl)methyl]phenol; 4-[(4-hydroxyphenyl)methyl]phenol

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

30th March, 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Other quality assurance:

ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)

Type of method:

effusion method: isothermal thermogravimetry

Test material

Test material information

Constituent 1

Reference substance name:

2-[(2-hydroxyphenyl)methyl]phenol; 2-[(4-hydroxyphenyl)methyl]phenol; 4-[(4-hydroxyphenyl)methyl]phenol

EC Number:

908-912-9

Cas Number:

1333-16-0

Molecular formula:

C39H36O6

IUPAC Name:

2-[(2-hydroxyphenyl)methyl]phenol; 2-[(4-hydroxyphenyl)methyl]phenol; 4-[(4-hydroxyphenyl)methyl]phenol

Test material form:

solid

Specific details on test material used for the study:

Manufacturer: Kukdo Chemical
Appearance: Solid
Chemical name: Bisphenol F
CAS: 1333-16-0
Purity: 98%

Results and discussion

Vapour pressure

Vapour pressure 1

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

0 Pa

Vapour pressure 2

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

0 mm Hg

Vapour pressure 3

Key result

Test no.:

#2

Temp.:

25 °C

Vapour pressure:

0 Pa

Vapour pressure 4

Key result

Test no.:

#2

Temp.:

25 °C

Vapour pressure:

0 mm Hg

Any other information on results incl. tables

The results of the isothermal TGA analysis for the test substance and vapor pressure at 20°C and 25 °C are given in the tables below. The plot of log PT of the test substance as a function of the reciprocal temperatures is shown in figure 2. The equation of the curve is log PT = 6143.6 x 1/T + 16.833 (r² = 0.9999, n = 7

Table 1 - Results of Isothermal TGA Analysis: 

Temperature (°C)	weight loss (g)	log Vt	log Pt	Pt
130	6.20x10E-5	-2.96	1.63	43.12
130	5.27 x 10 -5	-3.03	1.55	35.15
140	1.17 x 10 -4	-2.69	1.98	95.91
140	1.05 x 10 -4	-2.73	1.92	83.86
150	2.19 x 10 -4	-2.42	2.32	209.7
150	2.06 x 10 -4	-2.44	2.29	194.31
160	4.01 x 10 -4	-2.15	2.65	448.2
160	3.88 x 10 -4	-2.17	2.63	430.87
170	7.36 x 10 -4	-1.89	2.98	961.05
170	7.06 x 10 -4	-1.91	2.96	911.19
180	1.31 x 10 -3	-1.64	3.30	1982.81
180	1.24 x 10 -3	-1.66	3.27	1841.53
190	2.17 x 10 -3	-1.42	3.57	3740.31
190	2.03 x 10 -3	-1.45	3.54	3429.98

Table 2: Vapour pressure of the test substance:

Temperature (°C)	Log PT	PT (Pa)	PT (mmHg)
20	-4.14	7.3x10 -5	5.5x10 -7
25	-3.78	1.7x10 -4	1.2x10 -6
50	-2.19	6.5x10 -3	4.9x10 -5

Applicant's summary and conclusion

Conclusions:

The Isothermal TGA effusion method was used for the determination of vapor pressure of Bisphenol F. Vapor pressure of the test substance at 20 °C and 25°C was 5.5 x 10E-7 mmHg and 1.2 x 10E-6 mmHg.

Test item: Bisohenol F
Vapor pressure at 20°C - 7.3 x 10E-5 (5.5 x 10E-7 Pa)
Vapor pressure at 25 °C - 1.7x10E-4 (1.2 x 10E-6 Pa)

Executive summary:

Microbial degradation of Bisphenol-F (Reaction mass of 2,2’-methylenediphenol and 4,4’-methylenediphenol and o-[(4-hydroxyphenyl)methyl]phenol) was performed for 28 days following Testing Guidelines for Studies of Chemicals, Section 4.3, “Biodegradation Study (Ready Biodegradability) : Modified MITI(I)” (Notification No. 2017-4, issued by the National Institute of Environmental Research, Korea on March 14, 2017) and OECD Guidelines for Testing of Chemicals, 301C, “Ready Biodegradability-MITI(I) (Adopted : 17th July 1992)”.

The results of microbial degradation of Bisphenol-F(Reaction mass of 2,2’-methylenediphenol and 4,4’-methylenediphenol and o-[(4-hydroxyphenyl)methyl]phenol) were as follows;

The percentage biodegradations of the reference compound, Sodium benzoate, observed by BOD measurement were 86.2 % after 7 days and 85.7 % after 14 days. The test was valid that the results were within the acceptable range specified by the OECD guideline.

2) The percentage biodegradations of the test substance, Bisphenol-F(Reaction mass of 2,2’-methylenediphenol and 4,4’-methylenediphenol and o-[(4-hydroxyphenyl)methyl]phenol), observed by BOD measurement were calculated with a range of 31.8 ~ 33.9 % and the average percentage biodegradation was calculated to be 32.9 % after 28 days. Therefore, these results indicate that the test substance is not biodegradable in aqueous condition. The percentage biodegradation based on the residual amount of test substance by HPLC analysis was calculated to be 45.6 %.

As a result, the test substance could not be concluded as readily degradable by microorganisms in the aquatic environment because the percentage biodegradation of the test substance by BOD measurement was less than pass level for ready biodegradability (60%) specified by the OECD guideline.