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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: HPV report
Title:
Unnamed
Year:
2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Piperazine-1,4-diethanol
EC Number:
204-586-0
EC Name:
Piperazine-1,4-diethanol
Cas Number:
122-96-3
Molecular formula:
C8H18N2O2
IUPAC Name:
1,4-Bis(2-hydroxyethyl)piperazine

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Vehicle:
water
Doses:
14,700, 18,400, 23,800 and 25,000 mg/kg.
No. of animals per sex per dose:
5

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
18 738 mg/kg bw
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
20 093 mg/kg bw
Mortality:
At 14,700 mg/kg, 1/5 males and 0/5 females died; at 18,400 mg/kg, 1/5 males and 4/5 females died; at 23,800 mg/kg, 3/5 males and 3/5 females died; at 25,000 mg/kg, all animals died.
Clinical signs:
Clinical symptoms appeared approximately 1-4 hours after dosing. Clinical signs included: piloerection, apathy, passivity, twitching, hematuria and diarrhea. In some animals these symptoms progressed into a coma-like state followed by death.
Animals which survived the 72 hour period after dosing slowly recovered by day 5 and appeared normal at the end of the 14-day study period.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The rat oral LD50 was 20,093 and 18,738 mg/kg for males and females respectively.