Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-586-0 | CAS number: 122-96-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: HPV report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Piperazine-1,4-diethanol
- EC Number:
- 204-586-0
- EC Name:
- Piperazine-1,4-diethanol
- Cas Number:
- 122-96-3
- Molecular formula:
- C8H18N2O2
- IUPAC Name:
- 1,4-Bis(2-hydroxyethyl)piperazine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Vehicle:
- water
- Doses:
- 14,700, 18,400, 23,800 and 25,000 mg/kg.
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 18 738 mg/kg bw
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 20 093 mg/kg bw
- Mortality:
- At 14,700 mg/kg, 1/5 males and 0/5 females died; at 18,400 mg/kg, 1/5 males and 4/5 females died; at 23,800 mg/kg, 3/5 males and 3/5 females died; at 25,000 mg/kg, all animals died.
- Clinical signs:
- Clinical symptoms appeared approximately 1-4 hours after dosing. Clinical signs included: piloerection, apathy, passivity, twitching, hematuria and diarrhea. In some animals these symptoms progressed into a coma-like state followed by death.
Animals which survived the 72 hour period after dosing slowly recovered by day 5 and appeared normal at the end of the 14-day study period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The rat oral LD50 was 20,093 and 18,738 mg/kg for males and females respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
