Registration Dossier
Registration Dossier
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EC number: 204-586-0 | CAS number: 122-96-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Henry F. Smyth Jr. Ph.D., etc.
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, 23:2, 95-107. https://doi.org/10.1080/00028896209343211
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Eye injury in rabbits is recorded in a 10-grade ordinal series and is based upon the degree of corneal necrosis that results from instillation of various volumes and concentrations of chemical,for detail, see Carpenter, C.P. and H.F.Smyth,JR.: Chemical Burns of the Rabbit Cornea. Am.J.Ophthal.29:1363 (Nov,1946)
- GLP compliance:
- no
Test material
- Reference substance name:
- Piperazine-1,4-diethanol
- EC Number:
- 204-586-0
- EC Name:
- Piperazine-1,4-diethanol
- Cas Number:
- 122-96-3
- Molecular formula:
- C8H18N2O2
- IUPAC Name:
- 1,4-Bis(2-hydroxyethyl)piperazine
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.005 ml
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Grade
- Score:
- 5
- Remarks on result:
- other: severe burn
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Corrosive to eyes.
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