Registration Dossier
Registration Dossier
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EC number: 205-182-7 | CAS number: 135-19-3
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- other: Expert Assessment based on a literature review of the dissociation constants of 2-naphthol and read-across substances
- Adequacy of study:
- key study
- Study period:
- March 2021
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- An assessment was conducted using the available literature
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 9.63
- Temp.:
- 25 °C
- Conclusions:
- The pKa of 2-naphthol is 9.63 at 25 oC.
- Executive summary:
An expert assessment has been conducted for the dissociation constant of 2-naphthol based upon a literature review.
From the literature, the pKa of 2-naphthol is 9.63 at 25 oC according to the CRC Handbook of Chemistry and Physics (8th edition). The literature value for 2-naphthol is in good agreement with the read-across substance 1-naphthol which has a dissociation constant of 9.34 at 25 oC.
Reference
The pKa of 2-naphthol is 9.63 at 25 oC according to the CRC Handbook of Chemistry and Physics (8th edition). The literature value for 2-naphthol is in good agreement with the read-across substance 1-naphthol which has a dissociation constant of 9.34 at 25 oC. The slight increase of 0.3 could be due to the positioning of the hydroxyl group on the benzene ring.
Description of key information
An expert assessment has been conducted for the dissociation constant of 2-naphthol based upon a literature review.
From the literature, the pKa of 2-naphthol is 9.63 at 25 oC according to the CRC Handbook of Chemistry and Physics (8th edition). The literature value for 2-naphthol is in good agreement with the read-across substance 1-naphthol which has a dissociation constant of 9.34 at 25 oC.
Key value for chemical safety assessment
Additional information
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