Registration Dossier
Registration Dossier
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EC number: 205-182-7 | CAS number: 135-19-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
The genetic toxicity of 2-naphthol was evaluated based on available experimental data on 1-naphthol.
The substance 1-naphthol was identified as a suitable analogue based on comparison of available information on genotoxicity of the two substances, similar molecular structure and expected genotoxicity.
The capacity of 1-naphthol was investigated by conducting in vitro and in vivo testing. It was concluded that 1-naphthol did not meet the criteria for classification as mutagenic.
Based on this information, it is concluded that 2-naphthol is not expected to be genotoxic. It is not considered necessary to conduct further genotoxicity testing on the substance.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Description of key information
To assess the potential of 2-naphthol for inducing micronucleated erythrocytes, an in vivo micronucleus test was conducted on male mice using a method similar to the OECD Testing Guideline 474. The study was not GLP-compliant.
The results revealed that the frequency of MNPCE in any of the 2-Naphthol-treated groups was comparable to that in the negative control group and no statistically significant increase was found. No statistically significant decrease in the ratio of PCE to the analyzed erythrocytes was observed in any of the test substance-treated groups.
It was concluded that 2-naphthol did not induce micronucleated erythrocytes in mouse bone marrow cells, i.e. structural or numerical chromosome aberrations, under the conditions employed in this study.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
The capacity of 2-naphtol to induce structural or numerical chromosomal aberration in mammalian cells was investigated by performing an in vivo study similar to a relevant OECD 474 Testing Guideline. Results from the study were negative.
Moreover, the genetic toxicity of 2-naphthol was evaluated based on available experimental data on 1-naphthol, identified as a suitable analogue based on comparison of available information on genotoxicity of the two substances, similar molecular structure and expected genotoxicity. It was concluded that 1-naphthol did not meet the criteria for classification as mutagenic.
As a conclusion 2-naphthol does not meet the criteria for classification as mutagenic in accordance with Regulation (EC) No1272/2008.
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